Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK1 | Q13464 | 5/20 | 0.53 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.52 |
| ▸ | FAAH | O00519 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | GBA1 | P04062 | 6/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | ACHE | P22303 | 1/20 | 0.44 |
| ▸ | CNR2 | P34972 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9370301 | 0.93 | ROCK1 (0.57) | ROCK1ROCK2FAAHLMNAMEN1 | |
| SCHEMBL9374511 | 0.91 | GBA1 (0.44) | ROCK1ROCK2FAAHLMNAGBA1 | |
| SCHEMBL9370831 | 0.90 | ACHE (0.55) | ROCK1ROCK2FAAHLMNAMEN1 | |
| SCHEMBL9374517 | 0.87 | ROCK1 (0.56) | ROCK1ROCK2FAAHLMNAGBA1 | |
| SCHEMBL9371112 | 0.87 | ROCK1 (0.56) | ROCK1ROCK2FAAHLMNAMEN1 | |
| SCHEMBL9375978 | 0.87 | ROCK1 (0.56) | ROCK1ROCK2FAAHLMNAGBA1 | |
| SCHEMBL9376396 | 0.87 | ROCK1 (0.56) | ROCK1ROCK2FAAHLMNAGBA1 | |
| SCHEMBL9378618 | 0.87 | ROCK1 (0.56) | ROCK1ROCK2FAAHLMNAGBA1 | |
| SCHEMBL9371762 | 0.87 | FAAH (0.62) | ROCK1ROCK2FAAHLMNAGBA1 | |
| SCHEMBL9372912 | 0.85 | LMNA (0.59) | ROCK1ROCK2FAAHLMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0589985-A1 | 2-AMINO-4-ARYL-THIAZOLES WITH ANTIASTHMATIC AND ANTI-INFLAMMATORY ACTIVITIES ON THE RESPIRATORY TRACT | BOEHRINGER MANNHEIM ITALIA S.P.A. (IT) | 1994-04-06 | — | — | EP | disclosed |
| WO-1993000342-A1 | 2-AMINO-4-ARYL-THIAZOLES WITH ANTIASTHMATIC AND ANTI-INFLAMMATORY ACTIVITIES ON THE RESPIRATORY TRACT | BOEHRINGER MANNHEIM ITALIA S.P.A. (IT) | 1993-01-07 | — | — | WO | disclosed |
| EP-0519449-A1 | 2-Amino-4-aryl thiazoles with antiasthmatic and antiinflammatory activities on the respiratory tract | BOEHRINGER MANNHEIM ITALIA S.P.A. (IT) | 1992-12-23 | — | — | EP | disclosed |