Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 12/20 | 0.54 |
| ▸ | LMNA | P02545 | 7/20 | 0.53 |
| ▸ | MAPT | P10636 | 6/20 | 0.53 |
| ▸ | HTT | P42858 | 4/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 3/20 | 0.50 |
| ▸ | GAA | P10253 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.49 |
| ▸ | MGLL | Q99685 | 1/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | NPY2R | P49146 | 1/20 | 0.47 |
| ▸ | CNR1 | P21554 | 1/20 | 0.47 |
| ▸ | CNR2 | P34972 | 1/20 | 0.47 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.47 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9374499 | 0.93 | ALDH1A1 (0.50) | ALDH1A1LMNAMAPTHTTSMN1; SMN2 | |
| SCHEMBL9370254 | 0.93 | KMT2A (0.53) | ALDH1A1LMNAMAPTHTTSMN1; SMN2 | |
| SCHEMBL9376860 | 0.90 | MAPT (0.58) | ALDH1A1LMNAMAPTHTTSMN1; SMN2 | |
| SCHEMBL9370896 | 0.87 | KMT2A (0.50) | LMNAMAPTHTTSMN1; SMN2POLB | |
| SCHEMBL9370361 | 0.86 | FAAH (0.61) | ALDH1A1LMNAMAPTSMN1; SMN2CNR2 | |
| SCHEMBL9375923 | 0.83 | MAPT (0.53) | ALDH1A1LMNAMAPTHTTSMN1; SMN2 | |
| SCHEMBL9370589 | 0.83 | KMT2A (0.50) | ALDH1A1LMNAMAPTHTTSMN1; SMN2 | |
| SCHEMBL9371102 | 0.82 | KMT2A (0.46) | LMNAMAPTHTTSMN1; SMN2POLB | |
| SCHEMBL9370694 | 0.82 | KMT2A (0.48) | LMNAMAPTHTTSMN1; SMN2GAA | |
| SCHEMBL9371034 | 0.80 | KDM4E (0.48) | LMNAMAPTSMN1; SMN2KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0589985-A1 | 2-AMINO-4-ARYL-THIAZOLES WITH ANTIASTHMATIC AND ANTI-INFLAMMATORY ACTIVITIES ON THE RESPIRATORY TRACT | BOEHRINGER MANNHEIM ITALIA S.P.A. (IT) | 1994-04-06 | — | — | EP | disclosed |
| WO-1993000342-A1 | 2-AMINO-4-ARYL-THIAZOLES WITH ANTIASTHMATIC AND ANTI-INFLAMMATORY ACTIVITIES ON THE RESPIRATORY TRACT | BOEHRINGER MANNHEIM ITALIA S.P.A. (IT) | 1993-01-07 | — | — | WO | disclosed |
| EP-0519449-A1 | 2-Amino-4-aryl thiazoles with antiasthmatic and antiinflammatory activities on the respiratory tract | BOEHRINGER MANNHEIM ITALIA S.P.A. (IT) | 1992-12-23 | — | — | EP | disclosed |