Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 12/20 | 0.42 |
| ▸ | PDGFRA | P16234 | 12/20 | 0.42 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.41 |
| ▸ | IDO1 | P14902 | 2/20 | 0.41 |
| ▸ | TDO2 | P48775 | 2/20 | 0.41 |
| ▸ | NQO2 | P16083 | 1/20 | 0.38 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.35 |
| ▸ | GAK | O14976 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8502353 | 0.87 | TDO2 (0.50) | IDO1TDO2NQO2KDM4EALDH1A1 | |
| SCHEMBL18318661 | 0.78 | PDGFRB (0.49) | PDGFRBPDGFRAMALT1KDM4EALDH1A1 | |
| SCHEMBL3214752 | 0.78 | PDGFRB (0.49) | PDGFRBPDGFRAMALT1KDM4EALDH1A1 | |
| SCHEMBL22002092 | 0.77 | IDO1 (0.40) | MALT1IDO1TDO2NQO2KDM4E | |
| SCHEMBL8501180 | 0.76 | PDGFRB (0.46) | PDGFRBPDGFRAMALT1ALDH1A1 | |
| SCHEMBL8501715 | 0.71 | PDGFRB (0.56) | PDGFRBPDGFRA | |
| SCHEMBL18318734 | 0.70 | PDGFRB (0.51) | PDGFRBPDGFRANQO2ALDH1A1 | |
| SCHEMBL28235101 | 0.69 | TDO2 (0.42) | IDO1TDO2NQO2KDM4EALDH1A1 | |
| SCHEMBL14904070 | 0.68 | RAB9A (0.35) | IDO1TDO2NQO2KDM4EALDH1A1 | |
| SCHEMBL13255497 | 0.68 | HPGDS (0.60) | NQO2KDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0584222-A4 | BIS MONO-AND BICYCLIC ARYL AND HETEROARYL COMPOUNDS WHICH INHIBIT EGF AND/OR PDGF RECEPTOR TYROSINE KINASE | RHONE POULENC RORER INT (US) | 1994-07-06 | — | — | EP | disclosed |
| EP-0584222-A1 | BIS MONO-AND BICYCLIC ARYL AND HETEROARYL COMPOUNDS WHICH INHIBIT EGF AND/OR PDGF RECEPTOR TYROSINE KINASE. | RHONE POULENC RORER INT (US) | 1994-03-02 | — | — | EP | disclosed |