Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRA | P16234 | 8/20 | 0.59 |
| ▸ | PDGFRB | P09619 | 7/20 | 0.59 |
| ▸ | EHMT2 | Q96KQ7 | 2/20 | 0.48 |
| ▸ | DRD2 | P14416 | 1/20 | 0.45 |
| ▸ | DRD4 | P21917 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.43 |
| ▸ | AXL | P30530 | 1/20 | 0.43 |
| ▸ | FLT3 | P36888 | 1/20 | 0.43 |
| ▸ | MERTK | Q12866 | 1/20 | 0.43 |
| ▸ | EHMT1 | Q9H9B1 | 1/20 | 0.42 |
| ▸ | KIT | P10721 | 1/20 | 0.42 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.40 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.40 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.40 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30136401 | 0.87 | PDGFRB (0.52) | PDGFRAPDGFRBEHMT2 | |
| SCHEMBL4299023 | 0.77 | PDGFRB (1.00) | PDGFRAPDGFRBPDE10A | |
| SCHEMBL30997309 | 0.76 | PDGFRB (0.68) | PDGFRAPDGFRBPDE10A | |
| SCHEMBL30136402 | 0.76 | PDGFRB (0.56) | PDGFRAPDGFRBEHMT2EHMT1 | |
| Hydrochloric Acid SCHEMBL29357672 | 0.76 | PDGFRB (0.96) | PDGFRAPDGFRBPDE10A | |
| SCHEMBL30136394 | 0.75 | PDGFRB (0.51) | PDGFRAPDGFRBEHMT2DRD2DRD4 | |
| SCHEMBL30674692 | 0.75 | ALDH1A1 (0.57) | EHMT2HPGD | |
| SCHEMBL8389350 | 0.75 | PDGFRB (0.69) | PDGFRAPDGFRBPDE10A | |
| SCHEMBL30997286 | 0.74 | PDGFRB (0.64) | PDGFRAPDGFRBKDRPDE10A | |
| SCHEMBL24444648 | 0.74 | PDGFRB (0.59) | PDGFRAPDGFRBEHMT2KDREHMT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0584222-A4 | BIS MONO-AND BICYCLIC ARYL AND HETEROARYL COMPOUNDS WHICH INHIBIT EGF AND/OR PDGF RECEPTOR TYROSINE KINASE | RHONE POULENC RORER INT (US) | 1994-07-06 | — | — | EP | disclosed |
| EP-0584222-A1 | BIS MONO-AND BICYCLIC ARYL AND HETEROARYL COMPOUNDS WHICH INHIBIT EGF AND/OR PDGF RECEPTOR TYROSINE KINASE. | RHONE POULENC RORER INT (US) | 1994-03-02 | — | — | EP | disclosed |