Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | ABCC9 | O60706 | 6/20 | 0.35 |
| ▸ | F10 | P00742 | 1/20 | 0.34 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.34 |
| ▸ | PTGES | O14684 | 1/20 | 0.34 |
| ▸ | BACE1 | P56817 | 2/20 | 0.33 |
| ▸ | CTSD | P07339 | 1/20 | 0.33 |
| ▸ | TNKS | O95271 | 3/20 | 0.32 |
| ▸ | HTR1A | P08908 | 2/20 | 0.32 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.32 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.32 |
| ▸ | KCNJ8 | Q15842 | 1/20 | 0.32 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9373199 | 0.91 | ABCC9 (0.36) | MAOBABCC9F10MALT1BACE1 | |
| SCHEMBL9372567 | 0.81 | ADK (0.32) | — | |
| SCHEMBL9374693 | 0.78 | ABCC9 (0.33) | MAOBABCC9F10MALT1BACE1 | |
| SCHEMBL8088443 | 0.78 | MAOB (0.38) | MAOBABCC9F10MALT1PTGES | |
| SCHEMBL9372258 | 0.77 | ABCC9 (0.34) | ABCC9BACE1ABCB1 | |
| SCHEMBL8085327 | 0.77 | MAOB (0.37) | MAOBABCC9F10MALT1PTGES | |
| SCHEMBL9373191 | 0.77 | BACE1 (0.34) | MAOBABCC9F10BACE1HTR1A | |
| SCHEMBL9376800 | 0.76 | ABCC9 (0.38) | MAOBABCC9MALT1ABCC8KCNJ11 | |
| SCHEMBL10435504 | 0.76 | KDM4E (0.36) | MAOBF10 | |
| SCHEMBL9779684 | 0.76 | ABCC9 (0.37) | MAOBABCC9MALT1BACE1CTSD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0371312-B1 | Benzoxazine derivatives | MERCK PATENT GMBH (DE) | 1994-07-20 | — | — | EP | disclosed |
| US-5036068-A | Cardiovascular disorders | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1991-07-30 | — | — | US | disclosed |
| EP-0371312-A1 | Benzoxazine derivatives | MERCK PATENT GmbH (DE) | 1990-06-06 | — | — | EP | disclosed |