Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | GALR3 | O60755 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | GUSB | P08236 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | IGF1R | P08069 | 1/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9378850 | 0.79 | KMT2A (0.50) | HTTMEN1KMT2ARAB9ANPC1 | |
| SCHEMBL9374793 | 0.78 | CYP26A1 (0.53) | MEN1KMT2AMAPTMAPK14ALDH1A1 | |
| SCHEMBL9379254 | 0.78 | KMT2A (0.54) | MEN1KMT2ASMN1; SMN2RAB9ANPC1 | |
| SCHEMBL31411782 | 0.78 | STING1 (0.43) | MAPK14GAA | |
| SCHEMBL9375928 | 0.77 | MAPK14 (0.44) | MEN1KMT2ASMN1; SMN2RAB9ANPC1 | |
| SCHEMBL9376028 | 0.77 | NPC1 (0.49) | HTTMEN1KMT2ARAB9ANPC1 | |
| SCHEMBL9379514 | 0.77 | RAB9A (0.55) | MEN1KMT2ASMN1; SMN2RAB9ANPC1 | |
| SCHEMBL9375312 | 0.77 | HDAC1 (0.50) | MAPK14 | |
| SCHEMBL9375666 | 0.77 | NPC1 (0.59) | HTTMEN1KMT2ASMN1; SMN2RAB9A | |
| SCHEMBL9376520 | 0.76 | TOP1 (0.58) | HTTMEN1KMT2ASMN1; SMN2RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0344634-B1 | Bicyclic carboxamides, process for their preparation and medicaments containing them | BOEHRINGER MANNHEIM GMBH (DE) | 1994-03-30 | — | — | EP | disclosed |
| US-5019587-A | Anticoagulants | BOEHRINGER MANNHEIM GMBH (DE) | 1991-05-28 | — | — | US | disclosed |
| CN-1038640-A | Two ring carboxamide, its preparation methods and contain the pharmaceutical composition of this material | BOEHRINGER MANNHEIM GMBH (DE) | 1990-01-10 | — | — | CN | disclosed |