Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | KEAP1 | Q14145 | 3/20 | 0.41 |
| ▸ | NFE2L2 | Q16236 | 3/20 | 0.41 |
| ▸ | MAOB | P27338 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.40 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.40 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.40 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.40 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.40 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.40 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.39 |
| ▸ | PPARD | Q03181 | 1/20 | 0.39 |
| ▸ | TSPO | P30536 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9046522 | 0.92 | ALDH1A1 (0.52) | ALDH1A1TDP1MAOBMTNR1AMTNR1B | |
| SCHEMBL9350376 | 0.91 | TDP1 (0.46) | ALDH1A1TDP1KDM4EKEAP1NFE2L2 | |
| SCHEMBL10618638 | 0.91 | TDP1 (0.53) | TDP1KDM4EKEAP1NFE2L2MAOB | |
| SCHEMBL12280905 | 0.85 | TDP1 (0.46) | ALDH1A1TDP1KDM4EMEN1KMT2A | |
| SCHEMBL14654314 | 0.84 | TDP1 (0.57) | ALDH1A1TDP1KDM4EMEN1KMT2A | |
| SCHEMBL15267530 | 0.83 | TDP1 (0.43) | ALDH1A1TDP1KDM4EMEN1KMT2A | |
| SCHEMBL14654319 | 0.82 | TDP1 (0.47) | ALDH1A1TDP1KDM4EMEN1KMT2A | |
| SCHEMBL16519353 | 0.82 | TDP1 (0.65) | ALDH1A1TDP1KDM4EKEAP1NFE2L2 | |
| SCHEMBL16519356 | 0.82 | TDP1 (0.65) | ALDH1A1TDP1KDM4EKEAP1NFE2L2 | |
| SCHEMBL9350385 | 0.81 | NR1H4 (0.38) | ALDH1A1TDP1KEAP1NFE2L2MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0342891-B1 | Fluorescent intracellular calcium indicators | SMITHKLINE BEECHAM CORP (US) | 1994-03-09 | — | — | EP | disclosed |
| EP-0342891-A1 | Fluorescent intracellular calcium indicators | SMITHKLINE BEECHAM CORPORATION (US) | 1989-11-23 | — | — | EP | disclosed |
| US-4849362-A | Fluorescent intracellular calcium indicators | SMITHKLINE BECKMAN CORPORATION (US) | 1989-07-18 | — | — | US | disclosed |