Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 10/20 | 0.47 |
| ▸ | BCHE | P06276 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | NOS1 | P29475 | 5/20 | 0.37 |
| ▸ | NOS3 | P29474 | 2/20 | 0.37 |
| ▸ | NOS2 | P35228 | 2/20 | 0.37 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9381689 | 0.83 | ACHE (0.48) | ACHEBCHEMEN1USP2ALDH1A1 | |
| SCHEMBL9380862 | 0.82 | ACHE (0.47) | ACHEBCHEMEN1USP2ALDH1A1 | |
| SCHEMBL9382150 | 0.80 | ACHE (0.51) | ACHE | |
| SCHEMBL9380049 | 0.80 | ACHE (0.51) | ACHE | |
| SCHEMBL9385658 | 0.76 | ACHE (0.42) | ACHEBCHEMEN1USP2ALDH1A1 | |
| Peganole SCHEMBL4111529 | 0.75 | KLK7 (0.50) | ACHEBCHEMEN1USP2ALDH1A1 | |
| Peganole SCHEMBL30368933 | 0.75 | KLK7 (0.50) | ACHEBCHEMEN1USP2ALDH1A1 | |
| SCHEMBL9379522 | 0.75 | ACHE (0.44) | ACHEBCHEMEN1USP2ALDH1A1 | |
| SCHEMBL11521983 | 0.75 | NOS1 (0.36) | ACHEBCHEMEN1USP2ALDH1A1 | |
| SCHEMBL11521816 | 0.72 | NOS1 (0.39) | MEN1LMNACYP3A4KMT2ANOS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0597956-A1 | QUINAZOLINE DERIVATIVES AS ACETYLCHOLINESTERASE INHIBITORS | WARNER-LAMBERT COMPANY (US) | 1994-05-25 | — | — | EP | disclosed |