Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 1/20 | 0.51 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.51 |
| ▸ | PDE4A | P27815 | 7/20 | 0.50 |
| ▸ | PDE4B | Q07343 | 7/20 | 0.50 |
| ▸ | PDE4C | Q08493 | 7/20 | 0.50 |
| ▸ | PDE4D | Q08499 | 7/20 | 0.50 |
| ▸ | TOP1 | P11387 | 1/20 | 0.50 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.48 |
| ▸ | AURKA | O14965 | 1/20 | 0.46 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.43 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.43 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.43 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.43 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.43 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9375383 | 0.85 | KDM4E (0.51) | CLK4KCNA5AURKAGLO1SLC40A1 | |
| SCHEMBL9378645 | 0.80 | GABRG2 (0.44) | PDE4APDE4CPDE4DCYP19A1CYP1A2 | |
| SCHEMBL9375509 | 0.79 | PDE4D (0.51) | PDE4APDE4BPDE4CPDE4DKCNA5 | |
| SCHEMBL9376993 | 0.78 | DYRK1A (0.51) | DYRK1ACLK4TOP1KCNA5AURKA | |
| SCHEMBL15819347 | 0.76 | PDE4A (0.63) | DYRK1ACLK4PDE4APDE4BPDE4C | |
| SCHEMBL9375947 | 0.74 | CCR1 (0.42) | TOP1SLC40A1NPC1TP53CYP3A4 | |
| SCHEMBL9377158 | 0.72 | DYRK1A (0.54) | DYRK1ACLK4PDE4APDE4BPDE4C | |
| SCHEMBL10094648 | 0.72 | DYRK1A (0.62) | DYRK1ACLK4TOP1KCNA5AURKA | |
| SCHEMBL28824499 | 0.72 | CLK4 (0.62) | DYRK1ACLK4PDE4BTOP1KCNA5 | |
| SCHEMBL10094501 | 0.71 | DYRK1A (0.57) | DYRK1ACLK4PDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0612321-A1 | PYRIDO PYRIDAZINONE AND PYRIDAZINTHIONE COMPOUNDS WITH PDE IV INHIBITING ACTIVITY | SYNTEX (U.S.A.) INC. (US) | 1994-08-31 | — | — | EP | disclosed |