Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PYGM | P11217 | 1/20 | 0.43 |
| ▸ | TTBK1 | Q5TCY1 | 1/20 | 0.41 |
| ▸ | TTBK2 | Q6IQ55 | 1/20 | 0.41 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | DHODH | Q02127 | 1/20 | 0.38 |
| ▸ | PIM1 | P11309 | 2/20 | 0.38 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.37 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.37 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3915231 | 0.80 | BCAT2 (0.45) | PYGMTTBK1TTBK2PDPK1CA12 | |
| SCHEMBL4265706 | 0.69 | TAAR1 (0.50) | TTBK1TTBK2SMN1; SMN2LMNAAURKA | |
| SCHEMBL1059335 | 0.68 | PARP1 (0.44) | PYGMPDPK1CA12PARP1ALOX15 | |
| SCHEMBL3007353 | 0.67 | SRC (0.56) | CDK2AURKAABL1 | |
| SCHEMBL5329077 | 0.67 | PIM1 (0.47) | SMN1; SMN2PIM1PIM2GAAHPGD | |
| SCHEMBL23340785 | 0.67 | PNP (0.57) | POLBLMNAAURKA | |
| SCHEMBL29602318 | 0.67 | ROCK2 (0.61) | PDPK1CA12PARP1ALOX15SMN1; SMN2 | |
| SCHEMBL725815 | 0.67 | POLB (0.42) | TTBK1TTBK2PDPK1POLBLMNA | |
| SCHEMBL5355400 | 0.65 | CHUK (0.50) | TTBK1TTBK2EGFRROCK1MAPT | |
| SCHEMBL30162764 | 0.65 | CHUK (0.50) | TTBK1TTBK2EGFRROCK1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0327284-B1 | Triazolo(1,5-c)pyrimido(1,4) azines as bronchodilators | RIKER LABORATORIES INC (US) | 1994-08-17 | — | — | EP | disclosed |
| US-5166343-A | Chemical intermediates for bronchodilators | RIKER LABORATORIES, INC. (US) | 1992-11-24 | — | — | US | disclosed |
| US-5089493-A | Triazolo[1,5-C]pyrimido[1,4]azines as bronchodilators | RIKER LABORATORIES, INC. (US) | 1992-02-18 | — | — | US | disclosed |
| US-4981850-A | Triazolo[1,5-c]pyrimido[1,4]azines as bronchodilators | RIKER LABORATORIES, INC. (US) | 1991-01-01 | — | — | US | disclosed |
| EP-0327284-A2 | Triazolo(1,5-c)pyrimido(1,4) azines as bronchodilators | RIKER LABORATORIES, INC. (US) | 1989-08-09 | — | — | EP | disclosed |