Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 3/20 | 0.80 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.80 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.80 |
| ▸ | BACE1 | P56817 | 1/20 | 0.56 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.55 |
| ▸ | BCHE | P06276 | 1/20 | 0.55 |
| ▸ | EPOR | P19235 | 3/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | MAOB | P27338 | 4/20 | 0.53 |
| ▸ | KDM5A | P29375 | 1/20 | 0.53 |
| ▸ | FOS | P01100 | 1/20 | 0.51 |
| ▸ | JUN | P05412 | 1/20 | 0.51 |
| ▸ | APP | P05067 | 1/20 | 0.51 |
| ▸ | TLR4 | O00206 | 1/20 | 0.50 |
| ▸ | TLR2 | O60603 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9380767 | 1.00 | ALOX5 (0.80) | ALOX5PTGS1PTGS2BACE1ALOX5AP | |
| SCHEMBL9387791 | 0.91 | ALOX5 (0.66) | ALOX5PTGS1PTGS2BACE1ALOX5AP | |
| SCHEMBL9387783 | 0.91 | ALOX5 (0.66) | ALOX5PTGS1PTGS2BACE1ALOX5AP | |
| SCHEMBL9877287 | 0.89 | ALOX5 (1.00) | ALOX5PTGS1PTGS2BACE1ALOX5AP | |
| SCHEMBL6320363 | 0.87 | MAOB (0.62) | ALOX5PTGS1PTGS2BCHENPC1 | |
| SCHEMBL6318820 | 0.87 | MAOB (0.62) | ALOX5PTGS1PTGS2BCHENPC1 | |
| SCHEMBL9877809 | 0.83 | ALOX5 (0.76) | ALOX5PTGS1PTGS2BACE1ALOX5AP | |
| SCHEMBL7373223 | 0.83 | NPC1 (0.61) | ALOX5PTGS1PTGS2MEN1NPC1 | |
| SCHEMBL22024170 | 0.83 | NPC1 (0.61) | ALOX5PTGS1PTGS2MEN1NPC1 | |
| SCHEMBL7373222 | 0.83 | NPC1 (0.61) | ALOX5PTGS1PTGS2MEN1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0436199-B1 | Cyclopropyl derivative lipoxygenase inhibitors | ABBOTT LAB (US) | 1994-08-03 | — | — | EP | disclosed |
| US-5120752-A | N-(1-(20(3-pyridyloxy)phenyl)cyclopropyl) alkyl-N-hydroxyurea compounds, antiinflammatory agents | ABBOTT LABORATORIES (US) | 1992-06-09 | — | — | US | disclosed |
| US-5037853-A | Antiinflammatory agents | ABBOTT LABORATORIES (US) | 1991-08-06 | — | — | US | disclosed |
| EP-0436199-A1 | Cyclopropyl derivative lipoxygenase inhibitors | ABBOTT LABORATORIES (US) | 1991-07-10 | — | — | EP | disclosed |