Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 3/20 | 1.00 |
| ▸ | PTGS1 | P23219 | 2/20 | 1.00 |
| ▸ | PTGS2 | P35354 | 2/20 | 1.00 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.59 |
| ▸ | EPOR | P19235 | 3/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | KDM5A | P29375 | 1/20 | 0.53 |
| ▸ | BACE1 | P56817 | 1/20 | 0.53 |
| ▸ | BCHE | P06276 | 1/20 | 0.51 |
| ▸ | TLR4 | O00206 | 1/20 | 0.50 |
| ▸ | TLR2 | O60603 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9380757 | 0.89 | ALOX5 (0.80) | ALOX5PTGS1PTGS2ALOX5APEPOR | |
| SCHEMBL9380767 | 0.89 | ALOX5 (0.80) | ALOX5PTGS1PTGS2ALOX5APEPOR | |
| SCHEMBL9877809 | 0.86 | ALOX5 (0.76) | ALOX5PTGS1PTGS2ALOX5APEPOR | |
| SCHEMBL9781055 | 0.82 | ALOX5 (0.70) | ALOX5PTGS1PTGS2ALOX5APEPOR | |
| SCHEMBL9781059 | 0.82 | ALOX5 (0.70) | ALOX5PTGS1PTGS2ALOX5APEPOR | |
| SCHEMBL1206897 | 0.82 | ALOX5 (0.68) | ALOX5PTGS1PTGS2ALOX5APEPOR | |
| SCHEMBL1206895 | 0.82 | ALOX5 (0.68) | ALOX5PTGS1PTGS2ALOX5APEPOR | |
| SCHEMBL8494290 | 0.82 | ALOX5 (0.68) | ALOX5PTGS1PTGS2ALOX5APEPOR | |
| SCHEMBL7332640 | 0.82 | ALOX5 (0.68) | ALOX5PTGS1PTGS2ALOX5APEPOR | |
| SCHEMBL30014477 | 0.82 | ALOX5 (0.68) | ALOX5PTGS1PTGS2ALOX5APEPOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0196184-A2 | Aryl derivatives | THE WELLCOME FOUNDATION LIMITED (GB) | 1986-10-01 | — | — | EP | claimed |
| US-5036157-A | Hydroxamic acid derivatives, lipoxygenase and cyclooxygenase inhibitors, anticoagulants, antiinflammatory agents | BURROUGHS WELLCOME CO. | 1991-07-30 | — | — | US | disclosed |
| US-4977188-A | Hydroamic acid derivatives | BURROUGHS WELLCOME CO. (US) | 1990-12-11 | — | — | US | disclosed |
| WO-1990001929-A1 | NEW MEDICAL USE | THE WELLCOME FOUNDATION LIMITED (GB) | 1990-03-08 | — | — | WO | disclosed |
| US-4738986-A | CYCLOOXYGENASE, LIDOXYGENASE INHIBITORS | BURROUGHS WELLCOME CO. (US) | 1988-04-19 | — | — | US | disclosed |
| EP-0196184-A2 | Aryl derivatives | THE WELLCOME FOUNDATION LIMITED (GB) | 1986-10-01 | — | — | EP | disclosed |