Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 3/20 | 0.66 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.66 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.66 |
| ▸ | BCHE | P06276 | 3/20 | 0.53 |
| ▸ | ABCG2 | Q9UNQ0 | 3/20 | 0.51 |
| ▸ | MAOB | P27338 | 4/20 | 0.50 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.50 |
| ▸ | BACE1 | P56817 | 1/20 | 0.50 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.46 |
| ▸ | APP | P05067 | 1/20 | 0.46 |
| ▸ | EPOR | P19235 | 1/20 | 0.45 |
| ▸ | MAOA | P21397 | 1/20 | 0.45 |
| ▸ | P4HB | P07237 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9387783 | 1.00 | ALOX5 (0.66) | ALOX5PTGS1PTGS2BCHEABCG2 | |
| SCHEMBL9380767 | 0.91 | ALOX5 (0.80) | ALOX5PTGS1PTGS2BCHEMAOB | |
| SCHEMBL9380757 | 0.91 | ALOX5 (0.80) | ALOX5PTGS1PTGS2BCHEMAOB | |
| SCHEMBL9380196 | 0.84 | CA12 (0.60) | ALOX5PTGS1PTGS2BCHEABCG2 | |
| SCHEMBL9380189 | 0.84 | CA12 (0.60) | ALOX5PTGS1PTGS2BCHEABCG2 | |
| SCHEMBL23273749 | 0.83 | ALOX5 (0.58) | ALOX5PTGS1PTGS2BCHEABCG2 | |
| SCHEMBL6320363 | 0.83 | MAOB (0.62) | ALOX5PTGS1PTGS2BCHEABCG2 | |
| SCHEMBL6318820 | 0.83 | MAOB (0.62) | ALOX5PTGS1PTGS2BCHEABCG2 | |
| SCHEMBL9380275 | 0.82 | KDM4E (0.59) | ALOX5PTGS1PTGS2BCHEABCG2 | |
| SCHEMBL9380269 | 0.82 | KDM4E (0.59) | ALOX5PTGS1PTGS2BCHEABCG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0436199-B1 | Cyclopropyl derivative lipoxygenase inhibitors | ABBOTT LAB (US) | 1994-08-03 | — | — | EP | disclosed |
| US-5120752-A | N-(1-(20(3-pyridyloxy)phenyl)cyclopropyl) alkyl-N-hydroxyurea compounds, antiinflammatory agents | ABBOTT LABORATORIES (US) | 1992-06-09 | — | — | US | disclosed |
| EP-0436199-A1 | Cyclopropyl derivative lipoxygenase inhibitors | ABBOTT LABORATORIES (US) | 1991-07-10 | — | — | EP | disclosed |