Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.54 |
| ▸ | RAB9A | P51151 | 4/20 | 0.54 |
| ▸ | MAPT | P10636 | 4/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | ACHE | P22303 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | PTGS2 | P35354 | 6/20 | 0.51 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.51 |
| ▸ | MAOA | P21397 | 1/20 | 0.51 |
| ▸ | MAOB | P27338 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | APP | P05067 | 1/20 | 0.50 |
| ▸ | FBP1 | P09467 | 1/20 | 0.49 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.48 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.47 |
| ▸ | PIM1 | P11309 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9380814 | 1.00 | NPC1 (0.54) | NPC1RAB9AMAPTSMN1; SMN2MAPK1 | |
| SCHEMBL5514260 | 0.83 | ACHE (0.75) | NPC1RAB9AMAPTSMN1; SMN2MAPK1 | |
| SCHEMBL17589690 | 0.83 | ACHE (0.75) | NPC1RAB9AMAPTSMN1; SMN2MAPK1 | |
| SCHEMBL2681912 | 0.83 | ACHE (0.75) | NPC1RAB9AMAPTSMN1; SMN2MAPK1 | |
| SCHEMBL14129680 | 0.81 | KDM4E (0.53) | NPC1RAB9AMAPTSMN1; SMN2HTT | |
| SCHEMBL10388270 | 0.80 | RAB9A (0.65) | NPC1RAB9AMAPTSMN1; SMN2MAPK1 | |
| SCHEMBL10388268 | 0.80 | RAB9A (0.65) | NPC1RAB9AMAPTSMN1; SMN2MAPK1 | |
| SCHEMBL9382222 | 0.79 | MAPT (0.55) | NPC1RAB9AMAPTSMN1; SMN2MAPK1 | |
| SCHEMBL9382219 | 0.79 | MAPT (0.55) | NPC1RAB9AMAPTSMN1; SMN2MAPK1 | |
| SCHEMBL20464764 | 0.78 | SLC2A1 (0.56) | NPC1RAB9AMAPTSMN1; SMN2MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0356234-B1 | New Benzazole compounds, processes for the preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO (JP) | 1994-05-11 | — | — | EP | disclosed |
| US-5047411-A | Antiulcer Agents, H2-Receptor Antagonists | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1991-09-10 | — | — | US | disclosed |
| EP-0356234-A2 | New Benzazole compounds, processes for the preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1990-02-28 | — | — | EP | disclosed |