Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.36 |
| ▸ | PLK1 | P53350 | 1/20 | 0.36 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.36 |
| ▸ | GABRP | O00591 | 2/20 | 0.36 |
| ▸ | GABRD | O14764 | 2/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9381638 | 0.86 | GABRP (0.49) | KDM4EGAAKMT2AALDH1A1MAPT | |
| SCHEMBL9386680 | 0.84 | KDM4E (0.47) | KDM4EGAAKMT2AALDH1A1MAPT | |
| SCHEMBL9381680 | 0.80 | KDM4E (0.48) | KDM4EKMT2AMEN1RXFP1HSD17B10 | |
| SCHEMBL9381579 | 0.78 | P2RX4 (0.49) | KDM4EGAAKMT2AMEN1RXFP1 | |
| SCHEMBL9690959 | 0.70 | GABRP (0.59) | GAAKMT2AMEN1RXFP1HSD17B10 | |
| SCHEMBL9690819 | 0.69 | GABRP (0.53) | KDM4EGAAKMT2AMEN1RXFP1 | |
| SCHEMBL4495989 | 0.67 | KDM4E (0.82) | KDM4EGAAALDH1A1TSHRHSD17B10 | |
| Hydrochloric Acid SCHEMBL8984092 | 0.66 | KDM4E (0.80) | KDM4EGAAKMT2AALDH1A1MAPT | |
| SCHEMBL9062156 | 0.66 | ALDH1A1 (0.46) | KDM4EGAAKMT2AMEN1RXFP1 | |
| SCHEMBL9382438 | 0.65 | KDM4E (0.50) | KDM4EKMT2AMEN1ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0372962-B1 | Quinindolinone derivatives, process and intermediates for their preparation and pharmaceutical compositions containing them | BEECHAM GROUP PLC (GB) | 1994-07-20 | — | — | EP | claimed |
| EP-0372962-A2 | Quinindolinone derivatives, process and intermediates for their preparation and pharmaceutical compositions containing them | BEECHAM GROUP PLC (GB) | 1990-06-13 | — | — | EP | claimed |
| EP-0372962-B1 | Quinindolinone derivatives, process and intermediates for their preparation and pharmaceutical compositions containing them | BEECHAM GROUP PLC (GB) | 1994-07-20 | — | — | EP | disclosed |
| US-5079246-A | Antidepressants, anxiolytic agents | BEACHAM GROUP P. L. C. (GB) | 1992-01-07 | — | — | US | disclosed |
| EP-0372962-A2 | Quinindolinone derivatives, process and intermediates for their preparation and pharmaceutical compositions containing them | BEECHAM GROUP PLC (GB) | 1990-06-13 | — | — | EP | disclosed |