Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 6/20 | 0.64 |
| ▸ | HTR2A | P28223 | 6/20 | 0.64 |
| ▸ | HTR2C | P28335 | 4/20 | 0.64 |
| ▸ | ACHE | P22303 | 2/20 | 0.60 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.59 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9683993 | 0.92 | ACHE (0.62) | DRD2HTR2AHTR2CACHESLC6A4 | |
| SCHEMBL9683889 | 0.87 | DRD2 (0.61) | DRD2HTR2AHTR2CACHESLC6A4 | |
| SCHEMBL1545123 | 0.86 | HTR2A (0.60) | DRD2HTR2AHTR2CACHESLC6A4 | |
| SCHEMBL9381946 | 0.85 | HTR2A (0.82) | DRD2HTR2AHTR2CACHESLC6A4 | |
| SCHEMBL9684563 | 0.84 | ACHE (0.55) | DRD2HTR2AHTR2CACHESLC6A4 | |
| SCHEMBL9378325 | 0.83 | DRD2 (0.61) | DRD2HTR2AHTR2CACHESLC6A4 | |
| SCHEMBL1545818 | 0.83 | ACHE (0.72) | DRD2HTR2AHTR2CACHESLC6A4 | |
| SCHEMBL9684515 | 0.83 | HTR2A (0.56) | DRD2HTR2AHTR2CACHESLC6A4 | |
| SCHEMBL467202 | 0.82 | DRD2 (0.66) | DRD2HTR2AHTR2CACHESLC6A4 | |
| SCHEMBL8871775 | 0.79 | ACHE (0.77) | DRD2HTR2AHTR2CACHESLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0428437-B1 | 1,2-Benzisoxazole derivatives, process for their preparation and pharmaceutical compositions containing them | ADIR (FR) | 1994-08-17 | — | — | EP | disclosed |
| US-5134147-A | Antipsychotic agents | ADIR ET COMPAGNIE (FR) | 1992-07-28 | — | — | US | disclosed |
| US-5100902-A | Dopamine and Serotonin Antagonists, Antipsychotic Agents | ADIR ET COMPAGNIE (FR) | 1992-03-31 | — | — | US | disclosed |
| EP-0428437-A1 | 1,2-Benzisoxazole derivatives, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1991-05-22 | — | — | EP | disclosed |