Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.58 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.47 |
| ▸ | PPARD | Q03181 | 4/20 | 0.45 |
| ▸ | PPARA | Q07869 | 4/20 | 0.45 |
| ▸ | PPARG | P37231 | 1/20 | 0.45 |
| ▸ | MLYCD | O95822 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | CCR1 | P32246 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11074635 | 0.85 | MAPT (0.67) | MAPTHSD17B3PPARDPPARAPPARG | |
| SCHEMBL20639883 | 0.84 | PPARD (0.41) | MAPTHSD17B3PPARDPPARAPPARG | |
| SCHEMBL9039853 | 0.84 | MAPT (0.55) | MAPTPPARDPPARAPPARGHTT | |
| SCHEMBL11069441 | 0.83 | MAPT (0.64) | MAPTHSD17B3PPARDPPARAPPARG | |
| SCHEMBL14764626 | 0.82 | MAPT (0.66) | MAPTHSD17B3PPARDPPARAPPARG | |
| SCHEMBL13499379 | 0.82 | MAPT (0.60) | MAPTHSD17B3PPARDPPARAPPARG | |
| SCHEMBL9118588 | 0.81 | METAP2 (0.42) | MAPTPPARDPPARAHTTALDH1A1 | |
| SCHEMBL15912699 | 0.81 | MAPT (0.61) | MAPTHSD17B3PPARDPPARAPPARG | |
| SCHEMBL7451368 | 0.81 | MAPT (0.58) | MAPTHSD17B3PPARDPPARAPPARG | |
| SCHEMBL8501796 | 0.81 | MAPT (0.64) | MAPTHSD17B3PPARDPPARAPPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0331232-B1 | 5-lipoxygenase inhibiting 4-(4-phenyl-1-piperazinyl)phenols | JANSSEN PHARMACEUTICA NV (BE) | 1994-05-18 | — | — | EP | disclosed |
| US-4931444-A | FOR LEUKOTRIENE-MEDIATED DISEASES AND DISORDERS | JANSSEN PHARMACEUTICA N.V. (BE) | 1990-06-05 | — | — | US | disclosed |
| EP-0331232-A2 | 5-lipoxygenase inhibiting 4-(4-phenyl-1-piperazinyl)phenols | JANSSEN PHARMACEUTICA N.V. (BE) | 1989-09-06 | — | — | EP | disclosed |