Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C2 | P08235 | 1/20 | 0.42 |
| ▸ | AXL | P30530 | 4/20 | 0.41 |
| ▸ | GSK3A | P49840 | 3/20 | 0.38 |
| ▸ | GSK3B | P49841 | 3/20 | 0.38 |
| ▸ | SGK1 | O00141 | 3/20 | 0.38 |
| ▸ | CAMKK2 | Q96RR4 | 2/20 | 0.38 |
| ▸ | NEK1 | Q96PY6 | 1/20 | 0.38 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.37 |
| ▸ | MET | P08581 | 1/20 | 0.36 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.35 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9200857 | 0.90 | MAPT (0.41) | NR3C2AXLGSK3AGSK3BSGK1 | |
| SCHEMBL9580964 | 0.84 | CYP2C9 (0.51) | NR3C2AXLSGK1CAMKK2NEK1 | |
| SCHEMBL9705890 | 0.83 | NR3C2 (0.40) | NR3C2AXLGSK3AGSK3BPSMB5 | |
| SCHEMBL9580965 | 0.82 | CYP2C9 (0.48) | NR3C2AXLSGK1CAMKK2NEK1 | |
| SCHEMBL9463271 | 0.82 | NR3C2 (0.44) | NR3C2AXLGSK3AGSK3BSGK1 | |
| SCHEMBL9140284 | 0.79 | NR3C2 (0.44) | NR3C2AXLSGK1CAMKK2NEK1 | |
| SCHEMBL9463382 | 0.78 | NR3C2 (0.51) | NR3C2CYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL9205840 | 0.78 | KDM4E (0.48) | NR3C2AXLMETNPSR1KMT2A | |
| SCHEMBL9467948 | 0.78 | NR3C2 (0.62) | NR3C2AXLMETCYP1A2CYP3A4 | |
| SCHEMBL9415520 | 0.77 | MAPT (0.37) | NR3C2RIPK1CYP1A2CYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0538690-B1 | Arylquinoline substituted 1,4-dihydropyridine dicarboxylic derivatives, process for their preparation and their use as drugs | BAYER AG (DE) | 1994-09-28 | — | — | EP | disclosed |
| EP-0538690-A1 | Arylquinoline substituted 1,4-dihydropyridine dicarboxylic derivatives, process for their preparation and their use as drugs | BAYER AG (DE) | 1993-04-28 | — | — | EP | disclosed |