Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 1/20 | 0.51 |
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.45 |
| ▸ | PIK3CG | P48736 | 6/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 3/20 | 0.43 |
| ▸ | GRAMD1A | Q96CP6 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | GCK | P35557 | 1/20 | 0.42 |
| ▸ | OGA | O60502 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10825327 | 0.88 | GAA (0.42) | GRM5PIK3CGALDH1A1POLBGAA | |
| SCHEMBL3537610 | 0.86 | GRAMD1A (0.45) | GRM5PIK3CGALDH1A1POLBGAA | |
| SCHEMBL3541476 | 0.86 | GAA (0.46) | GRM5PIK3CGALDH1A1POLBGAA | |
| SCHEMBL10764703 | 0.84 | GRAMD1A (0.43) | PIK3CGALDH1A1POLBGAAGRAMD1A | |
| SCHEMBL10825473 | 0.84 | ALDH1A1 (0.44) | GRM5HCAR1PIK3CGALDH1A1POLB | |
| SCHEMBL3533467 | 0.84 | GRAMD1A (0.43) | GRM5PIK3CGALDH1A1POLBGAA | |
| SCHEMBL3538593 | 0.84 | GRM5 (0.54) | GRM5ALDH1A1GAANPC1RAB9A | |
| SCHEMBL3536221 | 0.83 | GRAMD1A (0.61) | GRAMD1AGCK | |
| SCHEMBL3534502 | 0.83 | GAA (0.43) | GRM5HCAR1ALDH1A1POLBGAA | |
| SCHEMBL3537071 | 0.83 | ALOX15 (0.44) | GRM5HCAR1PIK3CGALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0321191-B1 | Heterocyclic-substituted quinoline-carboxylic acids | PFIZER (US) | 1994-11-02 | — | — | EP | disclosed |
| US-5214051-A | Thiazolyl and oxazolyl[5,4-c]piperidyl-substituted quinolone-carboxylic acid and related analogs thereof having antibacterial properties are disclosed | PFIZER INC. (US) | 1993-05-25 | — | — | US | disclosed |
| US-5037834-A | Heterocycylic-substituted quinoline-carboxylic acids | PFIZER INC. (US) | 1991-08-06 | — | — | US | disclosed |
| WO-1989005643-A1 | HETEROCYCLIC-SUBSTITUTED QUINOLINE-CARBOXYLIC ACIDS | PFIZER INC. (US) | 1989-06-29 | — | — | WO | disclosed |
| EP-0321191-A2 | Heterocyclic-substituted quinoline-carboxylic acids | PFIZER INC. (US) | 1989-06-21 | — | — | EP | disclosed |