Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.59 |
| ▸ | PKM | P14618 | 2/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.58 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.58 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.58 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.56 |
| ▸ | ESR1 | P03372 | 2/20 | 0.54 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.54 |
| ▸ | CA12 | O43570 | 1/20 | 0.54 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.54 |
| ▸ | CA1 | P00915 | 1/20 | 0.54 |
| ▸ | CA2 | P00918 | 1/20 | 0.54 |
| ▸ | CA3 | P07451 | 1/20 | 0.54 |
| ▸ | TYR | P14679 | 1/20 | 0.54 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.54 |
| ▸ | CA4 | P22748 | 1/20 | 0.54 |
| ▸ | CA6 | P23280 | 1/20 | 0.54 |
| ▸ | DPP4 | P27487 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9380275 | 1.00 | KDM4E (0.59) | KDM4EALDH1A1PKMSMN1; SMN2ALOX5 | |
| SCHEMBL1206895 | 0.91 | ALOX5 (0.68) | KDM4EALDH1A1PKMSMN1; SMN2ALOX5 | |
| SCHEMBL1206897 | 0.91 | ALOX5 (0.68) | KDM4EALDH1A1PKMSMN1; SMN2ALOX5 | |
| SCHEMBL30014477 | 0.91 | ALOX5 (0.68) | KDM4EALDH1A1PKMSMN1; SMN2ALOX5 | |
| Hydrochloric Acid SCHEMBL11175049 | 0.89 | ALOX5 (0.67) | KDM4EALDH1A1PKMSMN1; SMN2ALOX5 | |
| SCHEMBL23273749 | 0.87 | ALOX5 (0.58) | KDM4EALDH1A1SMN1; SMN2ALOX5PTGS1 | |
| SCHEMBL28893713 | 0.87 | ALDH1A1 (0.57) | KDM4EALDH1A1PKMSMN1; SMN2ALOX5 | |
| SCHEMBL9379839 | 0.87 | THRB (0.64) | KDM4EALDH1A1PKMSMN1; SMN2ALOX5 | |
| SCHEMBL8783371 | 0.87 | ALDH1A1 (0.57) | KDM4EALDH1A1PKMSMN1; SMN2ALOX5 | |
| SCHEMBL8942607 | 0.87 | ALDH1A1 (0.57) | KDM4EALDH1A1PKMSMN1; SMN2ALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0436199-B1 | Cyclopropyl derivative lipoxygenase inhibitors | ABBOTT LAB (US) | 1994-08-03 | — | — | EP | disclosed |
| US-5120752-A | N-(1-(20(3-pyridyloxy)phenyl)cyclopropyl) alkyl-N-hydroxyurea compounds, antiinflammatory agents | ABBOTT LABORATORIES (US) | 1992-06-09 | — | — | US | disclosed |
| EP-0436199-A1 | Cyclopropyl derivative lipoxygenase inhibitors | ABBOTT LABORATORIES (US) | 1991-07-10 | — | — | EP | disclosed |