Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.44 |
| ▸ | BRD2 | P25440 | 1/20 | 0.44 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.44 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | POLB | P06746 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.41 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.41 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.41 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 4/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9388643 | 0.88 | BRD4 (0.47) | BRD4BRD2BRD3BRDTLMNA | |
| SCHEMBL10518334 | 0.80 | ACHE (0.43) | LMNAMAPTPOLBHTTCACNA1F | |
| SCHEMBL2647704 | 0.80 | CACNA1F (0.56) | LMNAMAPTPOLBCACNA1FCACNA1D | |
| SCHEMBL2662903 | 0.77 | CACNA1F (0.50) | LMNAMAPTPOLBCACNA1FCACNA1D | |
| SCHEMBL27310185 | 0.76 | CACNA1F (0.52) | LMNAMAPTPOLBCACNA1FCACNA1D | |
| SCHEMBL8949808 | 0.75 | CACNA1D (0.51) | LMNAMAPTPOLBCACNA1FCACNA1D | |
| SCHEMBL10424324 | 0.75 | CACNA1F (0.47) | LMNAMAPTPOLBCACNA1FCACNA1D | |
| SCHEMBL2648819 | 0.73 | CACNA1F (0.70) | LMNAMAPTPOLBMEN1KMT2A | |
| SCHEMBL8949895 | 0.73 | CACNA1D (0.49) | LMNAMAPTPOLBCACNA1FCACNA1D | |
| SCHEMBL8949606 | 0.72 | CACNA1F (0.48) | LMNAMAPTPOLBMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0378850-B1 | Substituted pyrido(2,3-d) pyrimidines | BAYER AG (DE) | 1994-04-06 | — | — | EP | disclosed |
| US-5145959-A | Enzyme inhibitors; antilipemic agents; treatment of atherosclerosis | BAYER AKTIENGESELLSCHAFT (DE) | 1992-09-08 | — | — | US | disclosed |
| US-5075311-A | Anticholesterol agents | BAYER AKTIENGESELLSCHAFT (DE) | 1991-12-24 | — | — | US | disclosed |