Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 5/20 | 0.47 |
| ▸ | BRDT | Q58F21 | 5/20 | 0.47 |
| ▸ | BRD2 | P25440 | 1/20 | 0.47 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.40 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.40 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.40 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9387828 | 0.88 | BRD4 (0.44) | BRD4BRDTBRD2BRD3LMNA | |
| SCHEMBL10518334 | 0.77 | ACHE (0.43) | LMNAKDM4ECACNA1FCACNA1DCACNA1S | |
| SCHEMBL2647704 | 0.76 | CACNA1F (0.56) | LMNAKDM4ECACNA1FCACNA1DCACNA1S | |
| SCHEMBL8949992 | 0.74 | CACNA1F (0.47) | LMNAKDM4ECACNA1FCACNA1DCACNA1S | |
| SCHEMBL2662903 | 0.73 | CACNA1F (0.50) | LMNAKDM4ECACNA1FCACNA1DCACNA1S | |
| SCHEMBL27310185 | 0.72 | CACNA1F (0.52) | LMNAKDM4ECACNA1FCACNA1DCACNA1S | |
| SCHEMBL8949895 | 0.72 | CACNA1D (0.49) | LMNAKDM4ECACNA1FCACNA1DCACNA1S | |
| SCHEMBL2648819 | 0.72 | CACNA1F (0.70) | LMNAKDM4ECACNA1FCACNA1DCACNA1S | |
| SCHEMBL8949808 | 0.71 | CACNA1D (0.51) | LMNAKDM4ECACNA1FCACNA1DCACNA1S | |
| SCHEMBL10424324 | 0.71 | CACNA1F (0.47) | LMNAKDM4ECACNA1FCACNA1DCACNA1S |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2247179-A | — | — | None | — | — | JP | disclosed |
| EP-0378850-B1 | Substituted pyrido(2,3-d) pyrimidines | BAYER AG (DE) | 1994-04-06 | — | — | EP | disclosed |
| US-5145959-A | Enzyme inhibitors; antilipemic agents; treatment of atherosclerosis | BAYER AKTIENGESELLSCHAFT (DE) | 1992-09-08 | — | — | US | disclosed |
| US-5075311-A | Anticholesterol agents | BAYER AKTIENGESELLSCHAFT (DE) | 1991-12-24 | — | — | US | disclosed |
| JP-H02247179-A | PYRIDO(2,3-D)PYRIMIDINE, ITS PREPARATION AND USE THEREOF | BAYER AG | 1990-10-02 | — | — | JP | disclosed |
| EP-0378850-A2 | Substituted pyrido(2,3-d) pyrimidines | BAYER AG (DE) | 1990-07-25 | — | — | EP | disclosed |