Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.61 |
| ▸ | NPC1 | O15118 | 3/20 | 0.55 |
| ▸ | MIF | P14174 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 6/20 | 0.53 |
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | CRHBP | P24387 | 2/20 | 0.49 |
| ▸ | CRHR2 | Q13324 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | RECQL | P46063 | 2/20 | 0.48 |
| ▸ | BLM | P54132 | 2/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | WNK1 | Q9H4A3 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9685901 | 0.81 | PKM (0.57) | PKMNPC1MAPTRAB9AMEN1 | |
| SCHEMBL9543716 | 0.79 | PKM (0.58) | PKMNPC1MAPTRAB9AMEN1 | |
| SCHEMBL8560755 | 0.78 | PKM (0.57) | PKMNPC1MAPTRAB9AMEN1 | |
| SCHEMBL9698164 | 0.77 | MAPT (0.63) | PKMMIFMAPTMEN1KMT2A | |
| SCHEMBL31631301 | 0.77 | NPC1 (0.74) | PKMNPC1MAPTRAB9AMEN1 | |
| SCHEMBL1738419 | 0.77 | NPC1 (0.74) | PKMNPC1MAPTRAB9AMEN1 | |
| SCHEMBL9538090 | 0.77 | TXNRD1 (0.60) | PKMNPC1MIFMAPTRAB9A | |
| SCHEMBL8134885 | 0.76 | PKM (0.61) | PKMNPC1MAPTRAB9AMEN1 | |
| SCHEMBL9630531 | 0.76 | PKM (1.00) | PKMNPC1MAPTRAB9AMEN1 | |
| SCHEMBL9634943 | 0.76 | PKM (0.57) | PKMNPC1MAPTRAB9AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1031403-C | Hydroxyalkylfuranyl derivatives | JANSSEN PHARMACEUTICA NV (BE) | 1996-03-27 | — | — | CN | disclosed |
| EP-0393738-B1 | Hydroxyalkylfuranyl derivatives | JANSSEN PHARMACEUTICA NV (BE) | 1994-11-30 | — | — | EP | disclosed |
| US-5272150-A | Hydroxyalkylfuranyl derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-12-21 | — | — | US | disclosed |
| EP-0393738-A1 | Hydroxyalkylfuranyl derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 1990-10-24 | — | — | EP | disclosed |
| CN-1046161-A | HYDROXYALKYLFURANYL DERIVATIVES | JANSSEN PHARMACEUTICA NV (BE) | 1990-10-17 | — | — | CN | disclosed |