Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.56 |
| ▸ | GAA | P10253 | 2/20 | 0.56 |
| ▸ | GLA | P06280 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.48 |
| ▸ | HPGD | P15428 | 4/20 | 0.48 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9384025 | 0.80 | KDM4E (0.54) | KDM4EGAAGLAPOLBTHRB | |
| SCHEMBL9384146 | 0.79 | KDM4E (0.64) | KDM4EGAAGLAPOLBTHRB | |
| SCHEMBL9389088 | 0.78 | POLB (0.47) | KDM4EGAAGLAPOLBTHRB | |
| SCHEMBL199891 | 0.78 | GAA (0.68) | KDM4EGAAGLAPOLBTHRB | |
| SCHEMBL12956838 | 0.77 | KDM4E (0.50) | KDM4EGAAGLAPOLBALDH1A1 | |
| SCHEMBL9383229 | 0.77 | ALDH1A1 (0.49) | KDM4EGAAGLAPOLBALDH1A1 | |
| SCHEMBL32688112 | 0.75 | KDM4E (0.56) | KDM4EGAAGLAPOLBTHRB | |
| SCHEMBL198335 | 0.72 | KDM4E (1.00) | KDM4EGAAGLAPOLBTHRB | |
| SCHEMBL14740380 | 0.72 | TGFBR1 (0.53) | KDM4EGAAGLAPOLBTHRB | |
| SCHEMBL9382960 | 0.71 | HTT (0.42) | KDM4EGAAGLAPOLBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0326981-B1 | 4-Oxo-4H-pyrido[1,2-a]pyrimidine-3-carboxamide derivatives, their preparation, medicaments containing them and their preparation | CHINOIN GYOGYSZER ES VEGYESZET (HU) | 1994-11-09 | — | — | EP | disclosed |
| EP-0326981-A2 | 4-Oxo-4H-pyrido[1,2-a]pyrimidine-3-carboxamide derivatives, their preparation, medicaments containing them and their preparation | CHINOIN Gyogyszer és Vegyészeti Termékek Gyára RT. (HU) | 1989-08-09 | — | — | EP | disclosed |