Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | AHR | P35869 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.35 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.35 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.35 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9387728 | 0.81 | HSD17B10 (0.43) | HSD17B10DYRK1AHDAC6HDAC3HDAC1 | |
| SCHEMBL9338940 | 0.76 | MAPT (0.42) | HSD17B10DYRK1AHDAC6MAOBNPC1 | |
| SCHEMBL9335011 | 0.75 | AKR1B1 (0.40) | HSD17B10DYRK1AAHRCSNK2A2CSNK2B | |
| SCHEMBL9335485 | 0.73 | NPC1 (0.37) | HSD17B10DYRK1AAHRMAOBF2RL3 | |
| SCHEMBL7961863 | 0.72 | DYRK1A (0.48) | DYRK1AHDAC6HDAC3HDAC1HDAC2 | |
| SCHEMBL9337325 | 0.71 | AHR (0.46) | DYRK1AHDAC6AHRCYP3A4CYP2C9 | |
| SCHEMBL9335081 | 0.71 | KAT8 (0.47) | HSD17B10DYRK1AHDAC6HDAC3HDAC1 | |
| SCHEMBL9388753 | 0.71 | KAT8 (0.47) | HSD17B10DYRK1AHDAC6HDAC3HDAC1 | |
| SCHEMBL9386691 | 0.69 | DYRK1A (0.40) | HSD17B10DYRK1AAHRMAOBF2RL3 | |
| SCHEMBL9339063 | 0.69 | CYSLTR1 (0.36) | HSD17B10DYRK1ACSNK2A2CSNK2BCSNK2A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0533695-B1 | IMIDAZO (4,5-c) PYRIDINES WITH PAF ANTAGONIST ACTIVITY | PFIZER (US) | 1994-10-05 | — | — | EP | disclosed |
| EP-0533695-A1 | IMIDAZO (4,5-c) PYRIDINES WITH PAF ANTAGONIST ACTIVITY. | PFIZER (US) | 1993-03-31 | — | — | EP | disclosed |
| WO-1991017163-A1 | IMIDAZO (4,5-c) PYRIDINES WITH PAF ANTAGONIST ACTIVITY | PFIZER INC. (US) | 1991-11-14 | — | — | WO | disclosed |