SCHEMBL939043

SCHEMBL939043

NC(c1ccccc1)C(O)C(=O)O

nearest known ligand 0.58

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
DPP4 P27487 2/20 0.56
LMNA P02545 4/20 0.54
MAPK1 P28482 1/20 0.54
CYP2D6 P10635 1/20 0.50
SRC P12931 1/20 0.50
HIF1A Q16665 2/20 0.46
KDM4E B2RXH2 2/20 0.46
ADRA2A P08913 1/20 0.45
ADRA2C P18825 1/20 0.45
GRM2 Q14416 1/20 0.44
GRM3 Q14832 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5860807 1.00 DPP4 (0.56) DPP4LMNAMAPK1CYP2D6SRC
SCHEMBL4073511 1.00 DPP4 (0.56) DPP4LMNAMAPK1CYP2D6SRC
SCHEMBL939042 1.00 DPP4 (0.56) DPP4LMNAMAPK1CYP2D6SRC
SCHEMBL8058962 1.00 DPP4 (0.56) DPP4LMNAMAPK1CYP2D6SRC
SCHEMBL487425 1.00 DPP4 (0.56) DPP4LMNAMAPK1CYP2D6SRC
SCHEMBL6027457 0.98 DPP4 (0.54) DPP4LMNAMAPK1CYP2D6SRC
Hydrochloric Acid SCHEMBL5860803 0.98 DPP4 (0.54) DPP4LMNAMAPK1CYP2D6SRC
Hydrochloric Acid SCHEMBL8073692 0.98 DPP4 (0.54) DPP4LMNAMAPK1CYP2D6SRC
Hydrochloric Acid SCHEMBL3184809 0.98 DPP4 (0.54) DPP4LMNAMAPK1CYP2D6SRC
Cadaverine Tartrate SCHEMBL30110790 0.91 DPP4 (0.64) DPP4LMNAMAPK1CYP2D6SRC

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 377 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-107406371-B Process for producing 3-phenylisoserine derivative 东丽精细化工株式会社 2020-07-17 CN claimed
EP-3266761-B1 3-PHENYLISOSERINE DERIVATIVE PRODUCTION METHOD TORAY FINECHEMICALS CO LTD (JP) 2020-05-06 EP claimed
US-10087139-B2 3-Phenylisoserine derivative production method TORAY FINE CHEMICALS CO., LTD. (JP) 2018-10-02 US claimed
US-20180237384-A1 3-PHENYLISOSERINE DERIVATIVE PRODUCTION METHOD TORAY FINE CHEMICALS CO., LTD. (JP) 2018-08-23 US claimed
EP-3266761-A1 3-PHENYLISOSERINE DERIVATIVE PRODUCTION METHOD Toray Fine Chemicals Co., Ltd. (JP) 2018-01-10 EP claimed
CN-107406371-A The manufacture method of 3 phenylisoserine derivatives 东丽精细化工株式会社 2017-11-28 CN claimed
EP-1961735-B1 Process for the preparation of (2r,3s)-3-phenylisoserine methyl ester acetate salt INDENA SPA (IT) 2009-11-18 EP claimed
CN-100348589-C Method and useful intermediates for paclitaxel synthesis from C-7, C-10 Di-CBZ Baccatin III NAPRO BIOTHERAPEUTICS INC (US) 2007-11-14 CN claimed
CN-1317271-C Process for preparing 4,10 beta-diacetoxy-2 alpha-benzoyloxy-5 beta, 20-epoxy-1, 13 alpha-dihydroxy-9-oxo-19-nor-cyclopropa [ g ] tax-11-ene AVENTIS PHARMA SA (FR) 2007-05-23 CN claimed
CN-1774430-A Process for the preparation of 4, 10 beta- diacetoxy-2 alpha-benzoyloxy-5 beta, 20-epoxy-1, 13 alpha-dihydroxy-9-oxo-19-norcyclopropa [g] tax-11-ene AVENTIS PHARMA SA (FR) 2006-05-17 CN claimed
US-5663393-A CYCLIZATION; DECYCLIZATION; HYDROLYSIS; HYDROGENATION RESEARCH CORPORATION TECHNOLOGIES, INC. (US) 1997-09-02 US claimed
EP-0682660-A4 1995-12-20 EP claimed
EP-0643626-A4 CHIRAL CATALYSTS, CATALYTIC OXIDATION AND DISPROPORTIONATION REACTIONS, AND METHODS OF PRODUCING EPOXYCHROMANS AND TAXOL. RES CORP TECHNOLOGIES INC (US) 1995-12-06 EP claimed
EP-0682660-A1 SYNTHESIS OF TAXOL, ANALOGS AND INTERMEDIATES WITH VARIABLE A-RING SIDE CHAINS BRYN MAWR COLLEGE (US) 1995-11-22 EP claimed
CN-1102829-A Synthesis of taxol, taxol analogs and intermediates thereof and compositions thereof BRYN MAWR COLLEGE (US) 1995-05-24 CN claimed
EP-0643626-A1 CHIRAL CATALYSTS, CATALYTIC OXIDATION AND DISPROPORTIONATION REACTIONS, AND METHODS OF PRODUCING EPOXYCHROMANS AND TAXOL RESEARCH CORPORATION TECHNOLOGIES, INC. (US) 1995-03-22 EP claimed
WO-1994018186-A1 SYNTHESIS OF TAXOL, ANALOGS AND INTERMEDIATES WITH VARIABLE A-RING SIDE CHAINS BRYN MAWR COLLEGE (US) 1994-08-18 WO claimed
US-RE34277-E Process for preparing taxol CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) 1993-06-08 US claimed
WO-1993003838-A1 CHIRAL CATALYSTS, CATALYTIC OXIDATION AND DISPROPORTIONATION REACTIONS, AND METHODS OF PRODUCING EPOXYCHROMANS AND TAXOL RESEARCH CORPORATION TECHNOLOGIES, INC. (US) 1993-03-04 WO claimed
US-4924011-A CONDENSATION, ESTERIFICATION; ANTITUMOR AND ANITLEUKEMIA AGENTS CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) 1990-05-08 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180237384-A1 3-PHENYLISOSERINE DERIVATIVE PRODUCTION METHOD SPTSSB, PIM3, TST DPP4 1591/4885LMNA 3094/4885MAPK1 1131/4885
US-10087139-B2 3-Phenylisoserine derivative production method SPTSSB, PIM3, TST DPP4 1591/4885LMNA 3094/4885MAPK1 1131/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.