Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.62 |
| ▸ | LMNA | P02545 | 3/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.59 |
| ▸ | GAA | P10253 | 1/20 | 0.59 |
| ▸ | GPR119 | Q8TDV5 | 7/20 | 0.55 |
| ▸ | NAMPT | P43490 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.52 |
| ▸ | MEN1 | O00255 | 3/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.50 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.50 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.50 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL381360 | 0.94 | MAPT (0.68) | MAPTLMNAALDH1A1KDM4EGAA | |
| SCHEMBL13279526 | 0.90 | MAPT (0.64) | MAPTLMNAALDH1A1KDM4EGAA | |
| SCHEMBL13281422 | 0.89 | MAPT (0.62) | MAPTLMNAALDH1A1KDM4EGAA | |
| SCHEMBL5573222 | 0.88 | MAPT (0.76) | MAPTLMNAALDH1A1KDM4EGAA | |
| SCHEMBL26823793 | 0.83 | MEN1 (0.57) | MAPTLMNAALDH1A1KDM4EGAA | |
| SCHEMBL2056118 | 0.82 | GPR119 (0.77) | MAPTLMNAALDH1A1KDM4EGAA | |
| SCHEMBL15441763 | 0.82 | GPR119 (0.81) | MAPTLMNAALDH1A1KDM4EGAA | |
| SCHEMBL2454198 | 0.81 | MAPT (0.64) | MAPTLMNAALDH1A1KDM4EGPR119 | |
| SCHEMBL2455257 | 0.81 | MAPT (0.64) | MAPTLMNAALDH1A1KDM4EGPR119 | |
| SCHEMBL20142379 | 0.81 | ALDH1A1 (0.67) | MAPTLMNAALDH1A1GPR119NAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1994020497-A1 | PYRROLO-PYRIDINE DERIVATIVES | MERCK SHARP & DOHME LIMITED (GB) | 1994-09-15 | — | — | WO | disclosed |