SCHEMBL9397186

SCHEMBL9397186

FC(F)(F)c1ccc(CCN2CCCNCC2)cc1

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SIGMAR1 Q99720 3/20 0.58
CXCR4 P61073 7/20 0.50
HRH3 Q9Y5N1 4/20 0.50
KCNH2 Q12809 2/20 0.50
TDP1 Q9NUW8 2/20 0.50
MEN1 O00255 1/20 0.50
CHRM2 P08172 1/20 0.50
CHRM1 P11229 1/20 0.50
ADRA2C P18825 1/20 0.50
CCR2 P41597 1/20 0.50
CXCL12 P48061 1/20 0.50
BLM P54132 1/20 0.50
KMT2A Q03164 1/20 0.50
KCNJ1 P48048 1/20 0.50
KDM4E B2RXH2 1/20 0.50
ALDH1A1 P00352 1/20 0.50
SLC6A4 P31645 2/20 0.49
SLC6A2 P23975 1/20 0.49
SLC6A3 Q01959 1/20 0.49
L3MBTL1 Q9Y468 2/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5450696 0.94 KCNH2 (0.55) SIGMAR1KCNH2TDP1BLMKCNJ1
Hydrochloric Acid SCHEMBL30152527 0.92 KCNH2 (0.54) SIGMAR1KCNH2TDP1BLMKCNJ1
SCHEMBL25541610 0.85 SIGMAR1 (0.60) SIGMAR1CXCR4HRH3KCNH2TDP1
SCHEMBL23632710 0.85 CXCR4 (0.71) SIGMAR1CXCR4HRH3TDP1MEN1
SCHEMBL5752571 0.83 KCNH2 (0.64) SIGMAR1CXCR4HRH3KCNH2TDP1
SCHEMBL22254774 0.80 HRH3 (0.72) SIGMAR1CXCR4HRH3KCNH2TDP1
SCHEMBL8668531 0.80 SLC6A3 (0.70) SIGMAR1CXCR4HRH3KCNH2TDP1
SCHEMBL22800902 0.78 SIGMAR1 (0.58) SIGMAR1HRH3KCNH2KCNJ1SLC6A4
Hydrochloric Acid SCHEMBL7983455 0.78 SLC6A3 (0.68) SIGMAR1CXCR4HRH3TDP1MEN1
SCHEMBL1882723 0.78 KDM4E (0.69) SIGMAR1CXCR4HRH3TDP1MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5340811-A Bronchodilator agent ASAHI KASEI KOGYO KABUSHIKI KAISHA (JP) 1994-08-23 US disclosed
EP-0471841-A1 SULFONAMIDE DERIVATIVE AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME Asahi Kasei Kogyo Kabushiki Kaisha (JP) 1992-02-26 EP disclosed