Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | NPY1R | P25929 | 1/20 | 0.47 |
| ▸ | NPY2R | P49146 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | THPO | P40225 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9397406 | 1.00 | LMNA (0.47) | LMNAHTTRXFP1TSHRALDH1A1 | |
| SCHEMBL9394665 | 0.92 | ADORA3 (0.51) | LMNAHTTRXFP1TSHRALDH1A1 | |
| SCHEMBL9394671 | 0.92 | ADORA3 (0.51) | LMNAHTTRXFP1TSHRALDH1A1 | |
| SCHEMBL9394617 | 0.85 | ADORA3 (0.59) | ALDH1A1SMN1; SMN2SLC29A1MAPK1ADORA3 | |
| SCHEMBL9393755 | 0.85 | ADORA3 (0.59) | ALDH1A1SMN1; SMN2SLC29A1MAPK1ADORA3 | |
| SCHEMBL6342419 | 0.75 | TSHR (0.72) | LMNAHTTRXFP1TSHRALDH1A1 | |
| SCHEMBL30047386 | 0.75 | TSHR (0.72) | LMNAHTTRXFP1TSHRALDH1A1 | |
| SCHEMBL3500846 | 0.75 | TSHR (0.72) | LMNAHTTRXFP1TSHRALDH1A1 | |
| SCHEMBL3500852 | 0.75 | TSHR (0.72) | LMNAHTTRXFP1TSHRALDH1A1 | |
| SCHEMBL28938381 | 0.75 | TSHR (0.52) | LMNAHTTRXFP1TSHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0365849-B1 | Novel 2'-halomethylidene, 2'-ethenylidene and 2'-ethynyl adenosine derivatives | MERRELL DOW PHARMA (US) | 1994-09-14 | — | — | EP | disclosed |
| EP-0365849-A2 | Novel 2'-halomethylidene, 2'-ethenylidene and 2'-ethynyl adenosine derivatives | MERRELL DOW PHARMACEUTICALS INC. (US) | 1990-05-02 | — | — | EP | disclosed |