Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHKA known ✓ | P35790 | 9/20 | 0.43 |
| ▸ | ACHE known ✓ | P22303 | 2/20 | 0.41 |
| ▸ | BCHE | P06276 | 2/20 | 0.41 |
| ▸ | KDM4A | O75164 | 2/20 | 0.40 |
| ▸ | KDM2A | Q9Y2K7 | 2/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31598838 | 0.83 | ALDH1A1 (0.50) | CHKABCHEACHEKDM4AKDM2A | |
| SCHEMBL24038376 | 0.82 | CHKA (0.49) | CHKABCHEACHEKDM4AKDM2A | |
| SCHEMBL12910774 | 0.82 | CHKA (0.49) | CHKABCHEACHEKDM4AKDM2A | |
| Bromide SCHEMBL9394629 | 0.80 | ACHE (0.52) | CHKABCHEACHEALDH1A1 | |
| Bromide SCHEMBL30071025 | 0.80 | ACHE (0.52) | CHKABCHEACHEALDH1A1 | |
| Bromide SCHEMBL5070701 | 0.80 | CHKA (0.53) | CHKAACHEALDH1A1 | |
| Hydrochloric Acid SCHEMBL25439461 | 0.80 | CHKA (0.47) | CHKABCHEACHEKDM4AKDM2A | |
| Hydrochloric Acid SCHEMBL25439458 | 0.80 | CHKA (0.47) | CHKABCHEACHEKDM4AKDM2A | |
| SCHEMBL1426439 | 0.78 | ALDH1A1 (0.52) | CHKAACHEALDH1A1 | |
| SCHEMBL17686001 | 0.78 | BCHE (0.48) | CHKABCHEACHEKDM4AKDM2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5334485-A | Containing n-heterocyclic ring | THE CHROMALINE CORPORATION (US) | 1994-08-02 | — | — | US | disclosed |