Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 3/20 | 0.35 |
| ▸ | GRM3 | Q14832 | 3/20 | 0.35 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.35 |
| ▸ | GRM8 | O00222 | 2/20 | 0.35 |
| ▸ | GRM6 | O15303 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | GRM5 | P41594 | 1/20 | 0.35 |
| ▸ | MTOR | P42345 | 1/20 | 0.35 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.35 |
| ▸ | PLCB1 | Q9NQ66 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | NSD2 | O96028 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL211075 | 0.88 | GRM2 (0.32) | GRM2GRM3GRM4GRM8GRM6 | |
| SCHEMBL27846113 | 0.81 | GRM4 (0.35) | GRM2GRM3GRM4GRM8GRM6 | |
| Cyclopentanamine SCHEMBL10816030 | 0.80 | GRM2 (0.31) | GRM2GRM3GRM4GRM8GRM6 | |
| Cyclohexylamine SCHEMBL10816957 | 0.78 | MMP8 (0.33) | CYP2C19 | |
| SCHEMBL4650803 | 0.78 | CYP2D6 (0.35) | GRM2GRM3GRM4GRM8GRM6 | |
| SCHEMBL5007908 | 0.77 | GRM4 (0.54) | GRM2GRM3GRM4GRM8GRM6 | |
| SCHEMBL5007910 | 0.77 | GRM4 (0.54) | GRM2GRM3GRM4GRM8GRM6 | |
| SCHEMBL3580225 | 0.77 | GRM2 (0.34) | GRM2GRM3GRM4GRM8GRM6 | |
| SCHEMBL5007909 | 0.77 | GRM4 (0.54) | GRM2GRM3GRM4GRM8GRM6 | |
| SCHEMBL7978037 | 0.77 | BTK (0.30) | GRM2GRM3GRM4GRM8GRM6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102712640-A | Tricyclic heterocyclic compounds, compositions and methods of use thereof | HOFFMANN LA ROCHE | 2012-10-03 | — | — | CN | disclosed |
| US-5276184-A | Curing agents for epoxy resins for thermosetting resins | THE DOW CHEMICAL COMPANY (US) | 1994-01-04 | — | — | US | disclosed |
| EP-0376959-B1 | PLATINUM PHARMACEUTICALS | GEORGETOWN UNIVERSITY (US) | 1993-03-24 | — | — | EP | disclosed |
| EP-0462980-A4 | PLATINUM PHARMACEUTICAL AGENTS | — | 1992-03-11 | — | — | EP | disclosed |
| EP-0462980-A1 | PLATINUM PHARMACEUTICAL AGENTS | GEORGETOWN UNIVERSITY (US) | 1992-01-02 | — | — | EP | disclosed |
| EP-0376959-A4 | PLATINUM PHARMACEUTICALS | — | 1990-11-22 | — | — | EP | disclosed |
| US-4946954-A | ANTICARCINOGENIC AGENTS | GEORGETOWN UNIVERSITY (US) | 1990-08-07 | — | — | US | disclosed |
| WO-1990008157-A1 | PLATINUM PHARMACEUTICAL AGENTS | GEORGETOWN UNIVERSITY (US) | 1990-07-26 | — | — | WO | disclosed |
| EP-0376959-A1 | PLATINUM PHARMACEUTICALS. | UNIV GEORGETOWN (US) | 1990-07-11 | — | — | EP | disclosed |
| US-4895935-A | ANTITUMOR | GEORGETOWN UNIVERSITY (US) | 1990-01-23 | — | — | US | disclosed |
| US-4895936-A | Water soluble anticancer agents | GEORGETOWN UNIVERSITY (US) | 1990-01-23 | — | — | US | disclosed |
| WO-1989000574-A1 | PLATINUM PHARMACEUTICALS | GEORGETOWN UNIVERSITY (US) | 1989-01-26 | — | — | WO | disclosed |