Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 10/20 | 0.65 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.54 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.53 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.53 |
| ▸ | PSMB2 | P49721 | 1/20 | 0.53 |
| ▸ | EBP | Q15125 | 1/20 | 0.52 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.52 |
| ▸ | ESR1 | P03372 | 7/20 | 0.51 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.49 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8932364 | 0.99 | LTA4H (0.63) | LTA4HPTGS2PSMB1PSMB5PSMB2 | |
| SCHEMBL9400242 | 0.89 | LTA4H (0.61) | LTA4HPSMB1PSMB5PSMB2EBP | |
| SCHEMBL227235 | 0.87 | LTA4H (0.61) | LTA4HPSMB1PSMB5PSMB2EBP | |
| SCHEMBL229153 | 0.87 | LTA4H (0.61) | LTA4HPSMB1PSMB5PSMB2EBP | |
| SCHEMBL7440123 | 0.84 | LTA4H (0.62) | LTA4HPSMB1PSMB5PSMB2ESR1 | |
| SCHEMBL7439644 | 0.84 | F2 (0.60) | LTA4HPSMB1PSMB5PSMB2EBP | |
| SCHEMBL7349591 | 0.82 | LTA4H (0.70) | LTA4HPSMB1PSMB5PSMB2HRH3 | |
| SCHEMBL7134872 | 0.80 | LTA4H (1.00) | LTA4HPTGS2PSMB1PSMB5PSMB2 | |
| SCHEMBL8951829 | 0.77 | ESR1 (0.58) | LTA4HPTGS2PSMB1PSMB5PSMB2 | |
| SCHEMBL13897535 | 0.77 | ESR1 (0.72) | LTA4HPSMB1PSMB5PSMB2EBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5354861-A | Binds to antiestrogen binding sites; antiproliferative activity | NATIONAL UNIVERSITY OF SINGAPORE (SG) | 1994-10-11 | — | — | US | claimed |