SCHEMBL9400328

SCHEMBL9400328

NCc1cccnc1-c1cccnc1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2A6 P11509 10/20 0.56
KCNA5 P22460 3/20 0.52
KCNN4 O15554 1/20 0.52
DPP4 P27487 1/20 0.50
LOXL2 Q9Y4K0 1/20 0.49
CYP3A4 P08684 3/20 0.48
ALDH1A1 P00352 2/20 0.48
CYP1A2 P05177 1/20 0.48
CYP2C9 P11712 4/20 0.47
CYP2B6 P20813 4/20 0.47
CYP2C19 P33261 4/20 0.47
CYP2E1 P05181 3/20 0.47
CYP2D6 P10635 3/20 0.47
CYP11B1 P15538 1/20 0.47
CYP11B2 P19099 1/20 0.47
CDK5 Q00535 1/20 0.44
CDK5R1 Q15078 1/20 0.44
PTGS2 P35354 1/20 0.43
KDM4E B2RXH2 1/20 0.42
LMNA P02545 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30332536 1.00 CYP2A6 (0.56) CYP2A6KCNA5KCNN4DPP4LOXL2
SCHEMBL5144683 0.84 CYP2A6 (0.58) CYP2A6KCNA5KCNN4CYP3A4ALDH1A1
SCHEMBL5616194 0.83 DPP4 (0.59) KCNA5KCNN4DPP4LOXL2CYP11B1
SCHEMBL439097 0.80 DPP4 (0.63) DPP4LOXL2KDM4E
SCHEMBL17531788 0.78 CYP2A6 (0.56) CYP2A6KCNA5KCNN4CYP3A4ALDH1A1
SCHEMBL29728289 0.78 KCNA5 (0.52) CYP2A6KCNA5KCNN4LOXL2CYP3A4
SCHEMBL3288245 0.78 DPP4 (0.46) CYP2A6KCNA5KCNN4DPP4LOXL2
SCHEMBL16634971 0.77 LOXL2 (0.44) CYP2A6KCNA5LOXL2CYP3A4ALDH1A1
SCHEMBL3288789 0.76 DPP4 (0.62) CYP2A6KCNA5DPP4LOXL2CYP3A4
SCHEMBL7092910 0.76 CYP2A6 (0.67) CYP2A6CYP3A4ALDH1A1CYP1A2CYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5342844-A 7-substituted quinolones and naphthyridones as antibacterial agents WARNER-LAMBERT COMPANY (US) 1994-08-30 US disclosed