Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Diethylamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 1/20 | 0.36 |
| ▸ | RIPK1 | Q13546 | 6/20 | 0.34 |
| ▸ | TP53 | P04637 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.32 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.32 |
| ▸ | FKBP5 | Q13451 | 1/20 | 0.32 |
| ▸ | CNR2 | P34972 | 1/20 | 0.32 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Diethylamine SCHEMBL7761030 | 0.92 | MEN1 (0.36) | POLBMEN1KMT2AKDM4ENPC1 | |
| Diethylamine SCHEMBL9233068 | 0.91 | RAB9A (0.38) | RIPK1POLBMEN1KMT2AKDM4E | |
| Diethylamine SCHEMBL9400483 | 0.89 | PPARG (0.35) | RIPK1TP53POLBMEN1KMT2A | |
| Diethylamine SCHEMBL9400385 | 0.89 | KDM4E (0.41) | POLBMEN1KMT2AKDM4ENPC1 | |
| Diethylamine SCHEMBL9400426 | 0.89 | RAB9A (0.39) | RIPK1TP53POLBMEN1KMT2A | |
| SCHEMBL9400402 | 0.89 | MAPT (0.39) | RIPK1TP53POLBMEN1KMT2A | |
| Diethylamine SCHEMBL9400410 | 0.88 | MAPT (0.34) | RIPK1TP53POLBMEN1KMT2A | |
| Diethylamine SCHEMBL9400390 | 0.88 | KMT2A (0.41) | RIPK1POLBMEN1KMT2AKDM4E | |
| Diethylamine SCHEMBL9400383 | 0.87 | LMNA (0.39) | TP53POLBMEN1KMT2AKDM4E | |
| Diethylamine SCHEMBL9400455 | 0.86 | KCNK9 (0.43) | TP53POLBMEN1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5372917-A | Excellent color forming property, storage stability and recorded image preservability; pyrazolone derivatives | KANZAKI PAPER MANUFACTURING CO., LTD. (JP) | 1994-12-13 | — | — | US | disclosed |