Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Diethylamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 5/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 4/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.36 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.36 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.34 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Diethylamine SCHEMBL9233068 | 0.96 | RAB9A (0.38) | RAB9ASMN1; SMN2MAPTNPC1POLB | |
| Diethylamine SCHEMBL7761030 | 0.95 | MEN1 (0.36) | RAB9ASMN1; SMN2MAPTNPC1POLB | |
| Diethylamine SCHEMBL9400506 | 0.93 | MEN1 (0.37) | RAB9ASMN1; SMN2MAPTNPC1POLB | |
| Diethylamine SCHEMBL9400442 | 0.91 | KCNK9 (0.43) | RAB9AMAPTNPC1POLBMEN1 | |
| Diethylamine SCHEMBL9400404 | 0.89 | POLB (0.37) | RAB9ASMN1; SMN2MAPTNPC1POLB | |
| Diethylamine SCHEMBL9400383 | 0.89 | LMNA (0.39) | RAB9ASMN1; SMN2MAPTNPC1POLB | |
| Diethylamine SCHEMBL9400407 | 0.89 | NTRK1 (0.36) | RAB9ANPC1POLBMEN1KMT2A | |
| Diethylamine SCHEMBL9400385 | 0.89 | KDM4E (0.41) | RAB9ASMN1; SMN2NPC1POLBMEN1 | |
| SCHEMBL9400423 | 0.88 | MAPT (0.42) | RAB9ASMN1; SMN2MAPTNPC1MEN1 | |
| Diethylamine SCHEMBL9400455 | 0.87 | KCNK9 (0.43) | RAB9ASMN1; SMN2NPC1POLBMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5372917-A | Excellent color forming property, storage stability and recorded image preservability; pyrazolone derivatives | KANZAKI PAPER MANUFACTURING CO., LTD. (JP) | 1994-12-13 | — | — | US | disclosed |