Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | LCK | P06239 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | GABRP | O00591 | 2/20 | 0.36 |
| ▸ | GABRD | O14764 | 2/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.36 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.36 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.36 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.36 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.36 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.36 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.36 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.36 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.36 |
| ▸ | GABRE | P78334 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9400445 | 0.90 | MAPK1 (0.41) | MAPK1LCKTSHRHPGDALDH1A1 | |
| SCHEMBL9400505 | 0.86 | CYP4A11 (0.43) | MAPK1LCKHPGDALDH1A1KDM4E | |
| SCHEMBL9400514 | 0.85 | CYP4A11 (0.42) | MAPK1LCKHPGDALDH1A1KDM4E | |
| SCHEMBL9400536 | 0.85 | MAPK1 (0.41) | MAPK1LCKHPGDALDH1A1KDM4E | |
| SCHEMBL9400469 | 0.81 | GABRA1 (0.36) | MAPK1LCKHPGDALDH1A1KDM4E | |
| SCHEMBL23088333 | 0.76 | ALDH1A1 (0.40) | MAPK1TSHRHPGDALDH1A1KDM4E | |
| SCHEMBL9400466 | 0.75 | MAPK1 (0.37) | MAPK1LCKHPGDALDH1A1KDM4E | |
| SCHEMBL9400428 | 0.74 | MPO (0.46) | MAPK1KDM4EGABRPGABRDGABRA1 | |
| SCHEMBL12466297 | 0.73 | TSHR (0.42) | TSHRHPGDALDH1A1KDM4EMAPT | |
| SCHEMBL10467645 | 0.72 | MAPK1 (0.52) | MAPK1LCKTSHRHPGDALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5356909-A | Substituted pyridine-2,4-dicarboxylic acid compounds and the use thereof and medicaments | HOECHST AKTIENGESELLSCHAFT (DE) | 1994-10-18 | — | — | US | disclosed |
| US-5143926-A | Substituted pyridine-2,4-dicarboxylic acid compounds and methods of use thereof | HOECHST AKTIENGESELLSCHAFT (DE) | 1992-09-01 | — | — | US | disclosed |
| US-5004748-A | Substituted pyridine-2,4-dicarboxylic acid derivatives and medicaments based on these compounds | HOECHST AKTIENGESELLSCHAFT (DE) | 1991-04-02 | — | — | US | disclosed |