Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 6/20 | 0.59 |
| ▸ | CDK2 | P24941 | 7/20 | 0.50 |
| ▸ | MAPT | P10636 | 5/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
| ▸ | HTR2B | P41595 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | HTR1D | P28221 | 1/20 | 0.40 |
| ▸ | HTR1B | P28222 | 1/20 | 0.40 |
| ▸ | HTR1F | P30939 | 1/20 | 0.40 |
| ▸ | HTR7 | P34969 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3351876 | 0.87 | CDK2 (0.48) | HTR6CDK2MAPTRXFP1MEN1 | |
| SCHEMBL3354579 | 0.86 | MAPT (0.47) | HTR6CDK2MAPTHTR2AHTR2C | |
| SCHEMBL9400557 | 0.83 | MAPT (0.51) | CDK2MAPTMEN1LMNAKMT2A | |
| SCHEMBL29540778 | 0.81 | MAPT (0.53) | CDK2MAPTMEN1LMNAKMT2A | |
| SCHEMBL3355596 | 0.80 | ALDH1A1 (0.55) | HTR6CDK2MAPTMEN1LMNA | |
| SCHEMBL3351522 | 0.79 | HTR6 (0.51) | HTR6CDK2MEN1LMNAKMT2A | |
| SCHEMBL3355597 | 0.79 | ALDH1A1 (0.57) | HTR6CDK2MEN1LMNAKMT2A | |
| SCHEMBL10577625 | 0.77 | CDK2 (0.46) | CDK2MAPTMEN1LMNAKMT2A | |
| SCHEMBL3352554 | 0.77 | KMT2A (0.51) | HTR6CDK2MAPTMEN1LMNA | |
| SCHEMBL3348930 | 0.76 | HTR6 (0.66) | HTR6HTR2AHTR2CHTR2BHTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2141163-A1 | Substituted thiazolidinones, their production and utilisation as medicine | Bayer Schering Pharma AG (DE) | 2010-01-06 | — | — | EP | disclosed |
| WO-1998047868-A1 | HETEROCYCLE-CONTAINING UREA DERIVATIVES AS 5HT1A, 5HT1B AND 5HT1D RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1998-10-29 | — | — | WO | disclosed |