Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.51 |
| ▸ | HTR1A | P08908 | 3/20 | 0.48 |
| ▸ | DRD3 | P35462 | 2/20 | 0.46 |
| ▸ | DRD2 | P14416 | 1/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.46 |
| ▸ | DRD4 | P21917 | 1/20 | 0.46 |
| ▸ | HTR2A | P28223 | 1/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9400960 | 0.96 | CYP2D6 (0.54) | CYP2D6ALDH1A1TSHRSIGMAR1HTR1A | |
| SCHEMBL9401021 | 0.86 | SLC6A4 (0.51) | CYP2D6ALDH1A1TSHRSIGMAR1HTR1A | |
| SCHEMBL9400941 | 0.83 | HSD17B10 (0.64) | SIGMAR1HTR1ADRD3DRD2DRD4 | |
| SCHEMBL9400948 | 0.82 | SLC6A4 (0.52) | CYP2D6SIGMAR1HTR1ADRD3DRD2 | |
| SCHEMBL9400953 | 0.81 | DRD2 (0.49) | CYP2D6ALDH1A1TSHRSIGMAR1DRD3 | |
| SCHEMBL7656340 | 0.81 | CYP2D6 (0.59) | CYP2D6HTR1ADRD3DRD2HTR2A | |
| SCHEMBL9401012 | 0.81 | HTR1A (0.55) | CYP2D6ALDH1A1TSHRHTR1ADRD3 | |
| SCHEMBL9400913 | 0.79 | HTR1A (0.76) | HTR1ADRD3DRD2 | |
| SCHEMBL9401042 | 0.79 | HSD17B10 (0.59) | SIGMAR1HTR1ADRD3DRD2DRD4 | |
| SCHEMBL9400951 | 0.79 | HTR1A (0.72) | HTR1ADRD3DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5314884-A | Antidepressants, anxiolytic agents | TROPONWERKE GMBH & CO. (DE) | 1994-05-24 | — | — | US | disclosed |
| US-5187276-A | Anxiolytics, neuroleptics, antidepressants, and nootropic agents | TROPONWERKE GMBH & CO. KG. (DE) | 1993-02-16 | — | — | US | disclosed |
| US-4988809-A | CENTRAL NERVOUS SYSTEM | TROPONWERKE GMBH & CO., KG (DE) | 1991-01-29 | — | — | US | disclosed |
| EP-0129128-B1 | 2-PYRIMIDINYL-1-PIPERAZINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND MEDICINES CONTAINING THEM | Troponwerke GmbH & Co. KG (DE) | 1990-11-22 | — | — | EP | disclosed |
| US-4937343-A | NEUROLEPTICS OR ANTIDEPRESSANTS | TROPONWERKE GMBH & CO. KG (DE) | 1990-06-26 | — | — | US | disclosed |
| US-4818756-A | CENTRAL NERVOUS SYSTEM DISORDERS | TROPONWERKE GMBH & CO., KG (DE) | 1989-04-04 | — | — | US | disclosed |