Known targets — ChEMBL curated mechanism
ABL1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB2AGTR1BCL2BCL2A1BCL2L1BCL2L10BCL2L2BCRBRAFCHRM1CHRNA10CHRNA9DRD1DRD2DRD3DRD4DRD5EGFRF2FLT1FLT4GCKGHSRGNRHRGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHTR1AHTR1BHTR1DHTR2AHTR2CHTR3AIDH2KDRKITMAOBMCL1MTTPPP4HBPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PIKFYVEROCK1ROCK2SLC18A2SLC6A2SLC6A3SLC6A4TACR1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8gyrAgyrBparCparEpol
The experimentally established mechanism targets of Phenol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL2L1 known ✓ | Q07817 | 1/20 | 0.43 |
| ▸ | MAOB known ✓ | P27338 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 2/20 | 0.61 |
| ▸ | CA2 | P00918 | 2/20 | 0.61 |
| ▸ | CA12 | O43570 | 1/20 | 0.61 |
| ▸ | GLA | P06280 | 1/20 | 0.61 |
| ▸ | CA3 | P07451 | 1/20 | 0.61 |
| ▸ | CA4 | P22748 | 1/20 | 0.61 |
| ▸ | CA9 | Q16790 | 1/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.61 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.61 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | CASP1 | P29466 | 1/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phenol SCHEMBL11211493 | 0.89 | TDP1 (0.61) | CA1CA2CA12GLACA3 | |
| Phenol SCHEMBL28121724 | 0.88 | TDP1 (0.69) | CA1CA2CA12GLACA3 | |
| Phenol SCHEMBL28096881 | 0.88 | TDP1 (0.69) | CA1CA2CA12GLACA3 | |
| Phenol SCHEMBL4576632 | 0.88 | TDP1 (0.69) | CA1CA2CA12GLACA3 | |
| Phenol SCHEMBL8801033 | 0.88 | TDP1 (0.69) | CA1CA2CA12GLACA3 | |
| Phenol SCHEMBL28187094 | 0.88 | TDP1 (0.69) | CA1CA2CA12GLACA3 | |
| Phenol SCHEMBL138896 | 0.88 | TDP1 (0.69) | CA1CA2CA12GLACA3 | |
| Phenol SCHEMBL6151178 | 0.86 | CA12 (0.58) | CA1CA2CA12GLACA3 | |
| Phenol SCHEMBL27646520 | 0.86 | TDP1 (0.58) | CA1CA2CA12GLACA3 | |
| Phenol SCHEMBL7217959 | 0.86 | CA12 (0.58) | CA1CA2CA12GLACA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103896809-B | The synthetic method of the naphthols mesylate of the amidino groups of Nafamostat Mesilate intermediate -6 2 | 北京蓝贝望生物医药科技股份有限公司 | 2017-12-08 | — | — | CN | claimed |
| CN-102633331-A | Method for treating high-concentration ammonia nitrogen in coking wastewater | CHANGZHOU YAHUAN ENVIRONMENTAL PROT TECHNOLOGY CO LTD | 2012-08-15 | — | — | CN | claimed |
| CN-102223890-A | For synthesis (Aib)8,35)hGLP-1(7-36)-NH2Method (2) | IPSEN MFG IRELAND LTD | 2011-10-19 | — | — | CN | claimed |
| WO-2023193831-A1 | PHOSPHATE OF TOLL-LIKE RECEPTOR INHIBITING COMPOUND AND PREPARATION METHOD THEREFOR | 北京拓领博泰生物科技有限公司 | 2023-10-12 | — | — | WO | disclosed |
| CN-110193011-A | A kind of phentolamine mesilate injection and preparation method thereof | 四川美大康华康药业有限公司 | 2019-09-03 | — | — | CN | disclosed |
| CN-109843935-A | Dispersion liquid | 住友化学株式会社 | 2019-06-04 | — | — | CN | disclosed |
| CN-109790028-A | Cleaning formulations for removing residues from semiconductor substrates | 富士胶片电子材料美国有限公司 | 2019-05-21 | — | — | CN | disclosed |
| CN-106928169-B | A kind of new skeleton sesquiterpenoid and the preparation method and application thereof | 成都中医药大学 | 2019-02-12 | — | — | CN | disclosed |
| CN-107751223-A | A kind of paichongding aqueous suspension agent containing alkaline antioxidant | 江苏克胜作物科技有限公司 | 2018-03-06 | — | — | CN | disclosed |
| CN-107698540-A | A kind of sesquiterpenoid and preparation method and application | 成都中医药大学 | 2018-02-16 | — | — | CN | disclosed |
| CN-107522594-A | A kind of sesquiterpenoid and preparation method and application | 成都中医药大学 | 2017-12-29 | — | — | CN | disclosed |
| CN-1512990-A | Substituted oxime derivatives and their use as latent acids | �������⻯ѧƷ�ع�����˾ | 2004-07-14 | — | — | CN | disclosed |
| CN-1456155-A | Mesilate phentolamine suppository and its preparation | TONGYAO MEDICINE CO LTD WUHAN (CN) | 2003-11-19 | — | — | CN | disclosed |
| CN-1103589-C | Method for modulating human sexual response | ZONAGEN INC (US) | 2003-03-26 | — | — | CN | disclosed |
| CN-1145380-A | Monozao compounds and dyeing or printing methods using the same | SUMITOMO CHEMICAL CO (JP) | 1997-03-19 | — | — | CN | disclosed |
| CN-1128950-A | Method for modulating human sexual response | ZONAGEN INC (US) | 1996-08-14 | — | — | CN | disclosed |
| US-4978757-A | BACTERICIDES, ANTITUMOR AGENTS, UV RAD ABSORBERS | THE UPJOHN COMPANY (US) | 1990-12-18 | — | — | US | disclosed |
| US-4912227-A | 1,2,8,8A-tetrahydrocyclopropa(c)pyrrolo(3,2-e)-indol-4-(5H)-ones and related compounds | THE UPJOHN COMPANY (US) | 1990-03-27 | — | — | US | disclosed |
| EP-0154445-B1 | ANALOGUES OF ANTIBIOTIC CC-1065 | THE UPJOHN COMPANY (US) | 1989-05-31 | — | — | EP | disclosed |
| EP-0154445-A1 | Analogues of antibiotic cc-1065 | THE UPJOHN COMPANY (US) | 1985-09-11 | — | — | EP | disclosed |