SCHEMBL9400915

SCHEMBL9400915

O=C(Cl)c1ccccc1Nc1cccc([N+](=O)[O-])c1

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
AKR1C3 P42330 3/20 0.57
AKR1C2 P52895 3/20 0.57
CTSV O60911 2/20 0.57
CTSL P07711 2/20 0.57
MAPT P10636 6/20 0.54
MEN1 O00255 6/20 0.54
KMT2A Q03164 6/20 0.54
POLB P06746 3/20 0.54
DDX3X O00571 2/20 0.54
HTT P42858 2/20 0.54
CTDSP1 Q9GZU7 1/20 0.54
ALDH1A1 P00352 4/20 0.52
RAB9A P51151 2/20 0.52
NPC1 O15118 1/20 0.52
KCNH2 Q12809 1/20 0.52
SMN1; SMN2 Q16637 2/20 0.51
TSHR P16473 1/20 0.51
MAPK13 O15264 1/20 0.50
MAPK12 P53778 1/20 0.50
MAPK11 Q15759 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4246352 0.87 CTSV (0.70) AKR1C3AKR1C2CTSVCTSLMAPT
SCHEMBL29779874 0.86 AKR1C3 (0.67) AKR1C3AKR1C2CTSVCTSLMAPT
SCHEMBL10822482 0.86 MAPT (0.65) AKR1C3AKR1C2CTSVCTSLMAPT
SCHEMBL11765925 0.84 MAPT (0.62) AKR1C3AKR1C2CTSVCTSLMAPT
SCHEMBL11762199 0.84 AKR1C3 (0.58) AKR1C3AKR1C2CTSVCTSLMAPT
SCHEMBL19657968 0.84 AKR1C3 (0.61) AKR1C3AKR1C2CTSVCTSLMAPT
SCHEMBL11763569 0.81 ABCG2 (0.57) AKR1C3AKR1C2CTSVCTSLMAPT
SCHEMBL11763360 0.80 SMN1; SMN2 (0.57) AKR1C3AKR1C2CTSVCTSLMAPT
SCHEMBL5250046 0.79 MEN1 (0.78) MAPTMEN1KMT2APOLBDDX3X
SCHEMBL11760920 0.79 ALDH1A1 (0.62) AKR1C3AKR1C2CTSVCTSLMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5314884-A Antidepressants, anxiolytic agents TROPONWERKE GMBH & CO. (DE) 1994-05-24 US disclosed
US-5187276-A Anxiolytics, neuroleptics, antidepressants, and nootropic agents TROPONWERKE GMBH & CO. KG. (DE) 1993-02-16 US disclosed
US-4988809-A CENTRAL NERVOUS SYSTEM TROPONWERKE GMBH & CO., KG (DE) 1991-01-29 US disclosed
EP-0129128-B1 2-PYRIMIDINYL-1-PIPERAZINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND MEDICINES CONTAINING THEM Troponwerke GmbH & Co. KG (DE) 1990-11-22 EP disclosed
US-4937343-A NEUROLEPTICS OR ANTIDEPRESSANTS TROPONWERKE GMBH & CO. KG (DE) 1990-06-26 US disclosed
US-4818756-A CENTRAL NERVOUS SYSTEM DISORDERS TROPONWERKE GMBH & CO., KG (DE) 1989-04-04 US disclosed
EP-0095641-B1 QUINAZOLINONE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE IN MEDICAMENTS Troponwerke GmbH & Co. KG (DE) 1987-07-29 EP disclosed
US-4539402-A ANTIINFLAMMATORY AGENTS TROPONWERKE GMBH & CO. (DE) 1985-09-03 US disclosed
EP-0129128-A2 2-Pyrimidinyl-1-piperazine derivatives, process for their preparation and medicines containing them Troponwerke GmbH & Co. KG (DE) 1984-12-27 EP disclosed
EP-0095641-A1 Quinazolinone derivatives, process for their preparation and their use in medicaments Troponwerke GmbH & Co. KG (DE) 1983-12-07 EP disclosed