SCHEMBL9401290

SCHEMBL9401290

COc1cc(OC)nc(SC(CO)C(C)(C)CBr)n1

nearest known ligand 0.37

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
AR P10275 2/20 0.36
ALDH1A1 P00352 1/20 0.34
ALOX5 P09917 7/20 0.33
PPARG P37231 4/20 0.33
PTGES O14684 3/20 0.33
ADORA3 P0DMS8 2/20 0.33
CYP1A2 P05177 1/20 0.33
ADORA1 P30542 1/20 0.33
PTGS2 P35354 1/20 0.32
PSEN1 P49768 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9401496 0.89 ALDH1A1 (0.34) ALDH1A1ALOX5PPARGPTGESADORA3
SCHEMBL9401466 0.87 ALDH1A1 (0.35) ALDH1A1ALOX5PPARGPTGESADORA3
SCHEMBL9401444 0.85 ALDH1A1 (0.37) ALDH1A1ADORA3CYP1A2ADORA1
SCHEMBL9401244 0.84 ADORA3 (0.35) ARALDH1A1ALOX5PPARGPTGES
SCHEMBL9401396 0.81 ALOX5 (0.38) ARALOX5PPARGPTGESADORA3
SCHEMBL9401563 0.81 ALDH1A1 (0.35) ALDH1A1ALOX5PPARGPTGESADORA3
SCHEMBL9401518 0.81 ALDH1A1 (0.36) ALDH1A1ALOX5PPARGPTGESADORA3
SCHEMBL9401420 0.80 ALOX5 (0.42) ALDH1A1ALOX5PPARGPTGESPSEN1
SCHEMBL9408872 0.79 ALDH1A1 (0.34) ARALDH1A1ALOX5PPARGPTGES
SCHEMBL9401542 0.78 ALOX5 (0.46) ALOX5PPARGPTGESPSEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5346880-A Pre- and postemergence NIHON BAYER AGROCHEM K.K. (JP) 1994-09-13 US disclosed
EP-0565951-A1 Herbicidally active pyrimidinylthioalkane derivatives NIHON BAYER AGROCHEM K.K. (JP) 1993-10-20 EP disclosed