SCHEMBL9401531

SCHEMBL9401531

COc1cc(OC)nc(SC(C=O)c2ccccc2F)n1

nearest known ligand 0.45

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
EDNRB P24530 1/20 0.37
EDNRA P25101 1/20 0.37
CTSA P10619 1/20 0.35
NPC1 O15118 1/20 0.33
CYP1A2 P05177 1/20 0.33
RAB9A P51151 1/20 0.33
ALDH1A1 P00352 1/20 0.33
LMNA P02545 1/20 0.33
MEN1 O00255 1/20 0.33
KMT2A Q03164 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9401252 0.85 CTSA (0.43) CTSAALDH1A1
SCHEMBL9401279 0.84 NPSR1 (0.37) CTSA
SCHEMBL9401207 0.84 NPC1 (0.34) CTSANPC1RAB9AALDH1A1LMNA
SCHEMBL9401440 0.81 PTGES (0.40) EDNRBEDNRAKMT2A
SCHEMBL9401354 0.78 GAA (0.39) EDNRBEDNRACYP1A2
SCHEMBL9401387 0.78 EDNRB (0.38) EDNRBEDNRA
SCHEMBL9401303 0.77 CTSA (0.34) CTSACYP1A2ALDH1A1
SCHEMBL9401347 0.76 MEN1 (0.39) CYP1A2MEN1KMT2A
SCHEMBL9401325 0.75 HTT (0.36) EDNRBEDNRACTSAALDH1A1LMNA
SCHEMBL9401445 0.75 EDNRB (0.44) EDNRBEDNRANPC1CYP1A2RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5346880-A Pre- and postemergence NIHON BAYER AGROCHEM K.K. (JP) 1994-09-13 US disclosed
EP-0565951-A1 Herbicidally active pyrimidinylthioalkane derivatives NIHON BAYER AGROCHEM K.K. (JP) 1993-10-20 EP disclosed