Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.56 |
| ▸ | TSHR | P16473 | 2/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.56 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | RGS12 | O14924 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | PKM | P14618 | 1/20 | 0.56 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.56 |
| ▸ | PLA2G2A | P14555 | 7/20 | 0.50 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8875796 | 0.85 | LMNA (0.68) | LMNACYP1A2CYP3A4CYP2C9TSHR | |
| SCHEMBL8292280 | 0.79 | LMNA (0.78) | LMNACYP1A2CYP3A4CYP2C9TSHR | |
| SCHEMBL9736956 | 0.77 | AKR1C3 (0.70) | LMNACYP1A2CYP3A4CYP2C9TSHR | |
| SCHEMBL11190363 | 0.75 | PLA2G2A (0.63) | LMNACYP1A2CYP3A4CYP2C9TSHR | |
| SCHEMBL8296317 | 0.74 | LMNA (0.69) | LMNACYP1A2CYP3A4CYP2C9TSHR | |
| SCHEMBL8643272 | 0.73 | LMNA (0.62) | LMNACYP1A2CYP3A4CYP2C9TSHR | |
| SCHEMBL10919513 | 0.73 | LMNA (0.60) | LMNACYP1A2CYP3A4CYP2C9TSHR | |
| SCHEMBL6437046 | 0.73 | PKM (0.81) | LMNACYP1A2CYP3A4CYP2C9TSHR | |
| SCHEMBL9735657 | 0.73 | CYP1A2 (0.59) | LMNACYP1A2CYP3A4CYP2C9TSHR | |
| SCHEMBL7963178 | 0.73 | PLA2G2A (0.65) | LMNACYP1A2CYP3A4CYP2C9TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5314898-A | Inhibitors of 5-lipoxygenase | MERCK & CO., INC. (US) | 1994-05-24 | — | — | US | disclosed |