Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 8/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.51 |
| ▸ | HTR3B | O95264 | 4/20 | 0.48 |
| ▸ | HTR3A | P46098 | 4/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | CNR2 | P34972 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | HTR3E | A5X5Y0 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9404529 | 0.85 | CYP1A2 (0.51) | CYP1A2CYP3A4CYP2D6MAPK1CYP2C19 | |
| SCHEMBL9404322 | 0.85 | POLB (0.41) | HRH4CYP1A2CYP3A4CYP2D6MAPK1 | |
| SCHEMBL9429950 | 0.83 | SMN1; SMN2 (0.54) | HRH4HTR3BHTR3ASMN1; SMN2MEN1 | |
| SCHEMBL5320912 | 0.74 | HTR3B (0.69) | HRH4CYP1A2CYP3A4CYP2D6MAPK1 | |
| SCHEMBL3668991 | 0.73 | RXFP1 (0.38) | CYP1A2CYP2D6CYP2C19MEN1KMT2A | |
| SCHEMBL30615144 | 0.73 | RXFP1 (0.38) | CYP1A2CYP2D6CYP2C19MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL11740107 | 0.72 | HTR3B (0.68) | HRH4CYP1A2CYP3A4CYP2D6MAPK1 | |
| SCHEMBL8210872 | 0.72 | ELANE (0.76) | CNR2 | |
| SCHEMBL4090855 | 0.71 | ABCB1 (0.62) | CYP1A2CYP3A4CYP2D6MAPK1CYP2C19 | |
| SCHEMBL21448035 | 0.70 | DRD2 (0.51) | HRH4CYP1A2CYP3A4CYP2D6MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5371080-A | Central nervous system disorders | NOVO NORDISK A/S | 1994-12-06 | — | — | US | disclosed |
| EP-0619820-A1 | IMIDAZOQUINAZOLINE COMPOUNDS AND THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 1994-10-19 | — | — | EP | disclosed |
| WO-1993013103-A1 | IMIDAZOQUINAZOLINE COMPOUNDS AND THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 1993-07-08 | — | — | WO | disclosed |