Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.31 |
| ▸ | PPARA | Q07869 | 1/20 | 0.41 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.34 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.33 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.33 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.33 |
| ▸ | CTRC | Q99895 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 5/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 4/20 | 0.31 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxalic Acid SCHEMBL9404480 | 0.84 | NOTUM (0.43) | CHRNB2CHRNA4SMN1; SMN2POLBSLC6A2 | |
| Oxalic Acid SCHEMBL9404430 | 0.83 | CHRNB2 (0.43) | CHRNB2CHRNA4SMN1; SMN2POLBJAK2 | |
| Oxalic Acid SCHEMBL9404484 | 0.79 | POLB (0.36) | CHRNA4RAB9AMAPTNPC1SMN1; SMN2 | |
| Oxalic Acid SCHEMBL9404365 | 0.78 | CHRM2 (0.51) | PPARACHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL9404483 | 0.76 | MAPT (0.34) | CHRNB2CHRNA4RAB9AHPGDMAPT | |
| Oxalic Acid SCHEMBL9404570 | 0.74 | PPARA (0.38) | PPARACHRNB2CHRNA4CTRCRAB9A | |
| SCHEMBL9404358 | 0.73 | PPARA (0.37) | PPARACHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL9404353 | 0.72 | TP53 (0.40) | PPARAMAPTMEN1KMT2AHTT | |
| Oxalic Acid SCHEMBL9404318 | 0.69 | CHRNA4 (0.31) | CHRNA4 | |
| SCHEMBL11721077 | 0.66 | PPARA (0.54) | PPARARAB9AHPGDMAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5356912-A | 3-(5-isoxazolyl)-1-methyl-1,2,3,6-tetrahydropyridine useful for treating Alzheimer's disease | NOVO NORDISK A/S (DK) | 1994-10-18 | — | — | US | disclosed |
| US-5262427-A | Cognition activators for Alzheimer*s disease | NOVO NORDISK A/S (DK) | 1993-11-16 | — | — | US | disclosed |
| EP-0316718-A2 | Azacyclic compounds and their preparation and use | NOVO NORDISK A/S (DK) | 1989-05-24 | — | — | EP | disclosed |