Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 2/20 | 0.32 |
| ▸ | DRD4 | P21917 | 2/20 | 0.32 |
| ▸ | DRD3 | P35462 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | STAT3 | P40763 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.30 |
| ▸ | MAPT | P10636 | 2/20 | 0.30 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9404276 | 0.85 | PRMT5 (0.34) | ALDH1A1RAB9AMAPTMEN1KMT2A | |
| SCHEMBL9404370 | 0.78 | CHRM2 (0.41) | PPARAHPGDRAB9ACHRM2CHRM4 | |
| SCHEMBL9404353 | 0.78 | TP53 (0.40) | PPARADRD2DRD4DRD3MAPT | |
| Oxalic Acid SCHEMBL9404355 | 0.73 | PPARA (0.41) | PPARAALDH1A1MAPK1SMN1; SMN2HPGD | |
| Oxalic Acid SCHEMBL9404275 | 0.67 | CHRM2 (0.42) | ALDH1A1RAB9AMAPTMEN1HTT | |
| SCHEMBL9404305 | 0.65 | PPARA (0.34) | PPARADRD2DRD4DRD3ALDH1A1 | |
| SCHEMBL9404576 | 0.63 | PPARA (0.34) | PPARAALDH1A1MAPK1HSD17B10TSHR | |
| Oxalic Acid SCHEMBL9404570 | 0.63 | PPARA (0.38) | PPARADRD2DRD4DRD3ALDH1A1 | |
| SCHEMBL9404481 | 0.62 | CHRM1 (0.41) | ALDH1A1SMN1; SMN2RAB9AMAPTMEN1 | |
| SCHEMBL10469531 | 0.61 | PPARA (0.46) | PPARAALDH1A1MAPK1SMN1; SMN2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5356912-A | 3-(5-isoxazolyl)-1-methyl-1,2,3,6-tetrahydropyridine useful for treating Alzheimer's disease | NOVO NORDISK A/S (DK) | 1994-10-18 | — | — | US | disclosed |
| US-5262427-A | Cognition activators for Alzheimer*s disease | NOVO NORDISK A/S (DK) | 1993-11-16 | — | — | US | disclosed |
| EP-0316718-A2 | Azacyclic compounds and their preparation and use | NOVO NORDISK A/S (DK) | 1989-05-24 | — | — | EP | disclosed |