Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.34 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.32 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | STAT3 | P40763 | 1/20 | 0.32 |
| ▸ | STAT1 | P42224 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 2/20 | 0.31 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.31 |
| ▸ | JAK2 | O60674 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxalic Acid SCHEMBL9404274 | 0.84 | CHRNB2 (0.34) | MAPTCHRNB2CHRNA4SLC6A2SLC6A4 | |
| Oxalic Acid SCHEMBL9404480 | 0.81 | NOTUM (0.43) | CHRNB2CHRNA4SLC6A2SLC6A4SLC6A3 | |
| Oxalic Acid SCHEMBL9404430 | 0.77 | CHRNB2 (0.43) | CHRNB2CHRNA4L3MBTL1SMN1; SMN2POLB | |
| Oxalic Acid SCHEMBL9404355 | 0.76 | PPARA (0.41) | MAPTCHRNB2CHRNA4SLC6A2SLC6A4 | |
| Oxalic Acid SCHEMBL9404484 | 0.73 | POLB (0.36) | MAPTCHRNA4SLC6A2SLC6A4SLC6A3 | |
| Oxalic Acid SCHEMBL9404318 | 0.64 | CHRNA4 (0.31) | CHRNA4 | |
| Oxalic Acid SCHEMBL9404275 | 0.64 | CHRM2 (0.42) | MAPTL3MBTL1RAB9ANPC1MEN1 | |
| Oxalic Acid SCHEMBL9404477 | 0.61 | CHRM3 (0.39) | MAPTL3MBTL1SMN1; SMN2RAB9ANPC1 | |
| SCHEMBL9404369 | 0.60 | ALDH1A1 (0.42) | MAPTL3MBTL1RAB9ANPC1MEN1 | |
| SCHEMBL9404358 | 0.60 | PPARA (0.37) | MAPTSMN1; SMN2RAB9AHPGDSTAT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5356912-A | 3-(5-isoxazolyl)-1-methyl-1,2,3,6-tetrahydropyridine useful for treating Alzheimer's disease | NOVO NORDISK A/S (DK) | 1994-10-18 | — | — | US | disclosed |
| US-5262427-A | Cognition activators for Alzheimer*s disease | NOVO NORDISK A/S (DK) | 1993-11-16 | — | — | US | disclosed |