Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 1/20 | 0.34 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 8/20 | 0.33 |
| ▸ | RAB9A | P51151 | 7/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9404358 | 0.85 | PPARA (0.37) | RAB9AKMT2AMEN1MAPTALDH1A1 | |
| SCHEMBL9404487 | 0.82 | P2RX7 (0.36) | NPC1RAB9AKMT2AL3MBTL1MAPT | |
| Oxalic Acid SCHEMBL9404275 | 0.82 | CHRM2 (0.42) | PRMT5WDR77NPC1RAB9AKMT2A | |
| SCHEMBL9404369 | 0.78 | ALDH1A1 (0.42) | PRMT5WDR77NPC1RAB9AKMT2A | |
| SCHEMBL9404481 | 0.77 | CHRM1 (0.41) | NPC1RAB9AKMT2AMEN1MAPT | |
| Oxalic Acid SCHEMBL9404274 | 0.73 | CHRNB2 (0.34) | NPC1RAB9AKMT2AMEN1L3MBTL1 | |
| SCHEMBL9404483 | 0.66 | MAPT (0.34) | NPC1RAB9AKMT2AMEN1L3MBTL1 | |
| SCHEMBL9404523 | 0.63 | RAB9A (0.35) | NPC1RAB9AKMT2AMEN1ALDH1A1 | |
| SCHEMBL9404353 | 0.63 | TP53 (0.40) | KMT2AMEN1MAPT | |
| Oxalic Acid SCHEMBL9404438 | 0.62 | SLC6A3 (0.33) | NPC1RAB9AKMT2AMEN1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5356912-A | 3-(5-isoxazolyl)-1-methyl-1,2,3,6-tetrahydropyridine useful for treating Alzheimer's disease | NOVO NORDISK A/S (DK) | 1994-10-18 | — | — | US | disclosed |
| US-5262427-A | Cognition activators for Alzheimer*s disease | NOVO NORDISK A/S (DK) | 1993-11-16 | — | — | US | disclosed |
| EP-0316718-A2 | Azacyclic compounds and their preparation and use | NOVO NORDISK A/S (DK) | 1989-05-24 | — | — | EP | disclosed |