Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 1/20 | 0.34 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.32 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.31 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | TSHR | P16473 | 2/20 | 0.31 |
| ▸ | XBP1 | P17861 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | STAT3 | P40763 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | IGF1R | P08069 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxalic Acid SCHEMBL9404570 | 0.73 | PPARA (0.38) | PPARACHRNB2CHRNA4NPC1RAB9A | |
| SCHEMBL9451949 | 0.71 | CHRNA1 (0.34) | PPARANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL9404305 | 0.65 | PPARA (0.34) | PPARANPC1RAB9ASMN1; SMN2S1PR1 | |
| Oxalic Acid SCHEMBL9404355 | 0.63 | PPARA (0.41) | PPARACHRNB2CHRNA4NPC1RAB9A | |
| SCHEMBL9404358 | 0.63 | PPARA (0.37) | PPARARAB9ASMN1; SMN2ALDH1A1TSHR | |
| Oxalic Acid SCHEMBL9404438 | 0.61 | SLC6A3 (0.33) | CHRNB2CHRNA4NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL9404353 | 0.59 | TP53 (0.40) | PPARANPSR1 | |
| SCHEMBL9404370 | 0.58 | CHRM2 (0.41) | PPARARAB9A | |
| SCHEMBL4030288 | 0.58 | SMN1; SMN2 (0.50) | PPARANPC1RAB9ASMN1; SMN2S1PR1 | |
| SCHEMBL11721077 | 0.58 | PPARA (0.54) | PPARANPC1RAB9ASMN1; SMN2S1PR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5356912-A | 3-(5-isoxazolyl)-1-methyl-1,2,3,6-tetrahydropyridine useful for treating Alzheimer's disease | NOVO NORDISK A/S (DK) | 1994-10-18 | — | — | US | disclosed |
| US-5262427-A | Cognition activators for Alzheimer*s disease | NOVO NORDISK A/S (DK) | 1993-11-16 | — | — | US | disclosed |
| EP-0316718-B1 | AZACYCLIC COMPOUNDS AND THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 1993-09-15 | — | — | EP | disclosed |
| EP-0316718-A2 | Azacyclic compounds and their preparation and use | NOVO NORDISK A/S (DK) | 1989-05-24 | — | — | EP | disclosed |