Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 4/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.36 |
| ▸ | HTR4 | Q13639 | 2/20 | 0.35 |
| ▸ | CHRM3 | P20309 | 4/20 | 0.31 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.31 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | CASP3 | P42574 | 1/20 | 0.31 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.31 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | RORC | P51449 | 1/20 | 0.30 |
| ▸ | USP7 | Q93009 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9404451 | 0.90 | OPRK1 (0.37) | PDE4APDE4BPDE4CPDE4DHTR4 | |
| SCHEMBL9404361 | 0.89 | HTR4 (0.35) | PDE4APDE4BPDE4CPDE4DHTR4 | |
| SCHEMBL9430240 | 0.89 | HRH4 (0.39) | HTR4OPRK1CYP2D6KCNH2USP7 | |
| SCHEMBL9429534 | 0.89 | SCN3A (0.34) | PDE4APDE4BPDE4CPDE4DHTR4 | |
| SCHEMBL7327494 | 0.86 | HTR4 (0.42) | PDE4APDE4BPDE4CPDE4DHTR4 | |
| SCHEMBL9429862 | 0.85 | HTR4 (0.34) | HTR4CHRM3OPRK1CHRM1POLB | |
| SCHEMBL9429875 | 0.85 | HTR4 (0.34) | HTR4CHRM3OPRK1CHRM1POLB | |
| SCHEMBL9404458 | 0.82 | HTR4 (0.35) | HTR4CHRM3CHRM1POLBCASP3 | |
| SCHEMBL9404462 | 0.82 | HTR4 (0.35) | HTR4CHRM3CHRM1POLBCASP3 | |
| SCHEMBL9404434 | 0.80 | HTR4 (0.34) | HTR4OPRK1CYP2D6KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0619820-A1 | IMIDAZOQUINAZOLINE COMPOUNDS AND THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 1994-10-19 | — | — | EP | claimed |
| WO-1993013103-A1 | IMIDAZOQUINAZOLINE COMPOUNDS AND THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 1993-07-08 | — | — | WO | claimed |
| US-5371080-A | Central nervous system disorders | NOVO NORDISK A/S | 1994-12-06 | — | — | US | disclosed |